{"id":1053031,"date":"2011-01-12T12:39:00","date_gmt":"2011-01-12T12:39:00","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/no-nsaid-may-be-safe-in-cardiovascular-terms-naproxen-seems-least-harmful\/"},"modified":"2024-08-17T18:47:37","modified_gmt":"2024-08-17T22:47:37","slug":"no-nsaid-may-be-safe-in-cardiovascular-terms-naproxen-seems-least-harmful","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/no-nsaid-may-be-safe-in-cardiovascular-terms-naproxen-seems-least-harmful.php","title":{"rendered":"No NSAID may be safe in cardiovascular terms – naproxen seems least harmful"},"content":{"rendered":"

\"\"<\/a>This BMJ meta-analysis<\/a> included large scale randomised controlled trials comparing any non-steroidal anti-inflammatory drug (NSAID) with other non-steroidal anti-inflammatory drugs or placebo. Data synthesis included 31 trials in 116,?429 patients. Patients were allocated to naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib, lumiracoxib, or placebo.<\/p>

Study outcomes<\/b><\/p>

The primary outcome was myocardial infarction. Secondary outcomes included stroke, death from cardiovascular disease, and death from any cause.<\/p>

Cardiovascular risks<\/b><\/p>

Compared with placebo, rofecoxib (Vioxx) was associated with the highest risk of myocardial infarction (rate ratio 2.12), followed by lumiracoxib (2.00).<\/p>

Ibuprofen was associated with the highest risk of stroke (3.36), followed by diclofenac (2.86).<\/p>

Etoricoxib (4.07) and diclofenac (3.98) were associated with the highest risk of cardiovascular death.<\/p>

Little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms. Naproxen (Aleve, Naprosyn) seemed least harmful.<\/p>

According to the corresponding BMJ editorial<\/a>, Celebrex (celecoxib) is not much safer either: \"All cyclo-oxygenase-2 inhibitors studied in large placebo controlled trials have been found to confer an increased risk of serious cardiovascular disease. This suggests that patients with a high risk of cardiovascular disease should avoid cyclo-oxygenase-2 inhibitors (COX-2). \"<\/p>

References<\/b><\/p>

Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis<\/a>. BMJ 2011; 342:c7086 doi: 10.1136\/bmj.c7086 (Published 11 January 2011)

Editorial: Cardiovascular safety of NSAIDs<\/a>. Wayne A Ray. BMJ 342:doi:10.1136\/bmj.c6618 (Published 11 January 2011)<\/p><\/div>

<\/div>
Image source: Wikipedia, public domain.<\/div>

Posted at Clinical Cases and Images<\/a>. Stay updated and subscribe<\/a>, follow us on Twitter<\/a> and connect on Facebook<\/a>.\"\"<\/p><\/div>

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<\/p>","protected":false},"excerpt":{"rendered":"

This BMJ meta-analysis included large scale randomised controlled trials comparing any non-steroidal anti-inflammatory drug (NSAID) with other non-steroidal anti-inflammatory drugs or placebo. Data synthesis included 31 trials in 116,?429 patients. Patients were allocated to naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053031","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053031"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053031"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053031\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}