{"id":1052861,"date":"2010-04-16T08:14:38","date_gmt":"2010-04-16T08:14:38","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/vitamin-d-deficiency-occurs-frequently-in-copd-and-correlates-with-severity\/"},"modified":"2024-08-17T18:46:27","modified_gmt":"2024-08-17T22:46:27","slug":"vitamin-d-deficiency-occurs-frequently-in-copd-and-correlates-with-severity","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/vitamin-d-deficiency-occurs-frequently-in-copd-and-correlates-with-severity.php","title":{"rendered":"Vitamin D deficiency occurs frequently in COPD and correlates with severity"},"content":{"rendered":"

\"\"<\/a>Serum 25-hydroxyvitamin D (25-OHD) levels were measured in 414 (ex)-smokers older than 50 years and the link between vitamin D status and presence of COPD was assessed. The rs7041 and rs4588 variants in the vitamin D-binding gene<\/b> (GC) were genotyped and their effects on 25-OHD levels were tested.<\/p>

In patients with COPD, 25-OHD levels correlated significantly with forced expiratory volume in 1 s (FEV1).<\/p>

Compared with 31% of the smokers with normal lung function, as many as 60% and 77% of patients with GOLD (Global Initiative for Obstructive Lung Disease) stage 3 and 4 exhibited deficient 25-OHD levels lower than 20 ng\/ml.<\/p>

25-OHD levels were reduced by 25% in homozygous carriers of the rs7041<\/b> at-risk allele. <\/p>

<\/div>
76% and 100% of patients with GOLD stage 3 and 4 homozygous for the rs7041<\/b> allele exhibited 25-OHD levels lower than 20 ng\/ml.

Vitamin D deficiency occurs frequently in COPD and correlates with severity of COPD. The data warrant vitamin D supplementation in patients with severe COPD, especially in those carrying at-risk rs7041<\/b> variants.<\/p>

References:<\/div>
Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax 2010;65:215-220 doi:10.1136\/thx.2009.120659.<\/div>
http:\/\/thorax.bmj.com\/content\/65\/3\/215.short<\/a><\/div>
Image source: Lungs<\/a>, Wikipedia, public domain.<\/div><\/div><\/div>

Posted at Clinical Cases and Images<\/a>. Stay updated and subscribe<\/a>, follow on Twitter<\/a> and Buzz<\/a>, and connect on Facebook<\/a>.\"\"<\/p><\/div>

<\/a>
<\/a><\/p>

<\/p>","protected":false},"excerpt":{"rendered":"

Serum 25-hydroxyvitamin D (25-OHD) levels were measured in 414 (ex)-smokers older than 50 years and the link between vitamin D status and presence of COPD was assessed. The rs7041 and rs4588 variants in the vitamin D-binding gene (GC) were genotyped … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1052861","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1052861"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1052861"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1052861\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1052861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1052861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1052861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}