{"id":1048328,"date":"2010-06-03T08:16:34","date_gmt":"2010-06-03T08:16:34","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/asms-forget-vioxx-eat-chocolate\/"},"modified":"2024-08-17T17:54:50","modified_gmt":"2024-08-17T21:54:50","slug":"asms-forget-vioxx-eat-chocolate","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/chemistry\/asms-forget-vioxx-eat-chocolate.php","title":{"rendered":"ASMS: Forget Vioxx, eat chocolate?"},"content":{"rendered":"<p><a href=\"http:\/\/prospect.rsc.org\/blogs\/cw\/wp-content\/uploads\/2010\/05\/hershey-kisses.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright alignnone size-medium wp-image-2897\" style=\"padding-left:10px; padding-right: 10px;\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/7f78b_hershey-kisses-300x275.jpg\" alt=\"\" width=\"187\" height=\"175\"><\/a>After sitting through a number of incredibly technical presentations today at ASMS I came across a fantastic poster presented by Shunyan Mo of the University of Illinois College of Pharmacy, US. Using an ultrafiltration LC-MS (liquid chromatography &ndash; mass spectrometry) assay, Mo and co-workers have shown that certain flavinoids found in cocoa selectively inhibit the cyclooxygenase-2 (Cox-2) enzyme and therefore could have anti-inflammatory effects.<\/p><p>As discussed in this <a href=\"http:\/\/www.rsc.org\/chemistryworld\/News\/2009\/September\/30090901.asp\" target=\"_blank\" rel=\"noopener\"><em>Chemistry World<\/em><\/a> article, Cox inhibitors such as naproxen play a vital role in the treatment of pain and inflammation, but they do have some side effects. To reduce these side effects, a number of pharmaceutical companies developed selective Cox-2 inhibitors, but unfortunately many of these were  linked to an increased risk of blood clotting, heart attack and stroke. In 2004, those risks caused a huge embarrassment for Merck &amp; Co., after it was forced to withdraw its blockbuster Cox-2 inhibitor Vioxx (<span>rofecoxib) costing the company in the region of $4.75 billion (&Acirc;&pound;3.3 billion) in legal settlements on top of the billions of dollars of lost sales.<\/span><span><\/span><\/p><div><\/div><p>But now, Mo has shown that eating chocolate might help reduce inflammation, and has identified using MS-MS experiments that two oxidation products of the abundant cocoa fatty acid, linoleic acid,&Acirc;&nbsp; 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) strongly and selectively inhibit Cox-2.<\/p><p>Perhaps unsurprisingly, the research was funded by US-confectionery company Hershey and the US National Institutes of Health (NIH).<\/p><p>So next time you need to reach for an anti-inflammatory, it might be worth reaching for a bar of chocolate instead &ndash; just don&rsquo;t blame me if you put on a few pounds!<\/p><p><em>Matt Wilkinson<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>After sitting through a number of incredibly technical presentations today at ASMS I came across a fantastic poster presented by Shunyan Mo of the University of Illinois College of Pharmacy, US. Using an ultrafiltration LC-MS (liquid chromatography &ndash; mass spectrometry) &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/chemistry\/asms-forget-vioxx-eat-chocolate.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246863],"tags":[],"class_list":["post-1048328","post","type-post","status-publish","format-standard","hentry","category-chemistry"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1048328"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1048328"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1048328\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1048328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1048328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1048328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}