{"id":1043519,"date":"2013-05-19T02:59:06","date_gmt":"2013-05-19T06:59:06","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/a-possible-biomarker-for-senescent-cells\/"},"modified":"2024-08-17T17:05:08","modified_gmt":"2024-08-17T21:05:08","slug":"a-possible-biomarker-for-senescent-cells","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-possible-biomarker-for-senescent-cells.php","title":{"rendered":"A Possible Biomarker for Senescent Cells"},"content":{"rendered":"

There are any number of techniques under development that allow individual cells to be destroyed provided that you can distinguish them from their neighbors: the challenge is in finding characteristic differences in the cells you want destroyed, such as cancer cells or senescent cells<\/a>. Most of the efforts aimed at producing targeted cell destruction therapies are taking place in the cancer research community, but senescent cells accumulate with age and contribute to degenerative aging<\/a> - they must also be destroyed<\/a>. Unfortunately good ways to target senescent cells are somewhat lacking<\/a>. Candidate mechanisms are emerging<\/a>, however, and here is another of them:<\/p>\n

Due to its role in aging and antitumor defense, cellular senescence has recently attracted increasing interest. However, [the] detection of senescent cells remains difficult due to the lack of specific biomarkers. ndeed, most determinants of cellular senescence, such as the upregulation of p53<\/a>, p16Ink4a<\/a>, p21WAF\/CIP1<\/a> or SASP<\/a>-associated cytokines<\/a>, are not exclusively observed in senescence, but can also occur in other types of stress responses. In addition, alterations like SAHF<\/a> or DNA-SCARS<\/a> formation are frequently observed, but not necessarily a mandatory feature or exclusive to senescent cells.<\/p>\n

The current gold standard for the detection of senescence is the so-called senescence-associated ?-galactosidase (SA-?-Gal)<\/a> activity. Although SA-?-Gal has been first suggested as a distinct enzyme, its activity is derived from lysosomal<\/a> ?-Gal encoded by the GLB1<\/a> gene. ?-Gal is an accepted marker of senescence, but its reliability and specificity have been questioned, as a positive ?-Gal reaction has also been detected in human cancer cells that were chemically induced to differentiate, or upon contact inhibition. Moreover, several cell types, such as epithelial cells<\/a> and murine<\/a> fibroblasts<\/a> generally show a weak ?-Gal staining.<\/p>\n

In the present study, we investigated several lysosomal hydrolases<\/a> for their suitability as senescence markers and identified ?-fucosidase<\/a>, a lysosomal glycosidase involved in the breakdown of glycoproteins, oligosaccharides and glycolipids, as a novel biomarker for senescence. We demonstrate that ?-fucosidase is upregulated [in] all canonical types of cellular senescence, including replicative, DNA damage- and oncogene-induced senescence. Our results suggest that detection of ?-fucosidase might be a highly valuable biomarker for senescence in general and in particular in those cases where SA-?-Gal activity fails to properly discriminate between senescent- and non-senescent cells.<\/i><\/p><\/blockquote>\n

Link: http:\/\/www.landesbioscience.com\/journals\/cc\/article\/24944\/?show_full_text=true<\/a><\/span><\/p>\n

Source:
http:\/\/www.fightaging.org\/archives\/2013\/05\/a-possible-biomarker-for-senescent-cells.php<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

There are any number of techniques under development that allow individual cells to be destroyed provided that you can distinguish them from their neighbors: the challenge is in finding characteristic differences in the cells you want destroyed, such as cancer … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043519","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043519"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043519"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043519\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}