{"id":1043481,"date":"2013-03-03T02:56:52","date_gmt":"2013-03-03T07:56:52","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/infusing-large-numbers-of-immune-cells-as-a-therapy\/"},"modified":"2024-08-17T17:04:53","modified_gmt":"2024-08-17T21:04:53","slug":"infusing-large-numbers-of-immune-cells-as-a-therapy","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/infusing-large-numbers-of-immune-cells-as-a-therapy.php","title":{"rendered":"Infusing Large Numbers of Immune Cells as a Therapy"},"content":{"rendered":"

Since it is possible to take a patient's cells and generate a very large number of immune cells<\/a>, far more than the patient would ever have normally, and since it's possible to make some alterations to immune cells to make them more effective, why not do this?<\/a> It's probably the case that even generally healthy older people would benefit from a regular infusion of large numbers of their own immune cells, or even donor cells, given the way in which the immune system declines with age<\/a>, but under present medical regulation you'll only ever see it deployed as a treatment for late stage disease:<\/p>\n

[Researchers] have successfully infused large numbers of donor T-cells<\/a> specific for a key anti-leukemic antigen<\/a> to prolong survival in high-risk and relapsed leukemia patients after stem cell transplantation. [T-cells were] taken from a donor, programmed in the lab to recognize the Wilm's Tumor Antigen 1 (WT1)<\/a> and kill leukemia<\/a> cells, grown in large numbers, and then infused into patients to promote anti-leukemic activity. The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic.<\/p>\n

All of the patients [received] adoptively transferred infusions of billions of enhanced CD8<\/a> cytotoxic T-cell clones. They were considered at high risk of death because they had already relapsed and\/or had a poor prognosis due to unfavorable characteristics of their leukemia.<\/p>\n

Four of the 11 patients in the trial received infusions of T-cells that targeted WT1 and were generated in the presence of IL-21<\/a>. One had detectable relapsed disease and entered complete remission shortly after the T-cells were infused. All four survived after T-cell therapy without relapse for more than 30 months without suffering graft-vs.-host-disease<\/a> and required no additional anti-leukemic treatment, according to the study.<\/p>\n

Among the seven patients who received infused T-cells generated without the presence of IL-21, two showed direct evidence of anti-leukemic activity, including one patient with advanced progressive disease who had a temporary response.<\/i><\/p><\/blockquote>\n

Link: http:\/\/www.sciencedaily.com\/releases\/2013\/02\/130227151248.htm<\/a><\/span><\/p>\n

Source:
http:\/\/www.fightaging.org\/archives\/2013\/02\/infusing-large-numbers-of-immune-cells-as-a-therapy.php<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Since it is possible to take a patient's cells and generate a very large number of immune cells, far more than the patient would ever have normally, and since it's possible to make some alterations to immune cells to make … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043481","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043481"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043481"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043481\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043481"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043481"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}