{"id":1043437,"date":"2012-12-02T07:49:45","date_gmt":"2012-12-02T07:49:45","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/kynurenine-tryptophan-metabolism-and-fly-longevity\/"},"modified":"2024-08-17T17:04:33","modified_gmt":"2024-08-17T21:04:33","slug":"kynurenine-tryptophan-metabolism-and-fly-longevity","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/kynurenine-tryptophan-metabolism-and-fly-longevity.php","title":{"rendered":"Kynurenine-Tryptophan Metabolism and Fly Longevity"},"content":{"rendered":"<p><a href=\"http:\/\/en.wikipedia.org\/wiki\/Metabolism\">Metabolism<\/a> is a very complex set of overlapping mechanisms, feedback loops, and networks of protein interactions. So even if there are only a few core methods of extending life by altering metabolism in a species, we should expect to see scores of different ways to trigger some or all of that alteration - and with widely varying side-effects. This is one of the present challenges facing those researchers who focus on how metabolism and genes determine natural variations in longevity: mapping it all for any one species is a vast task.<\/p>\n<p>Here is one example of ongoing research drawn from among the many ways to make flies live longer:<\/p>\n<blockquote><p><i>Up-regulation of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Kynurenine\">kynurenine (KYN)<\/a> pathway of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Tryptophan\">tryptophan (TRP)<\/a> was suggested as one of the mechanisms of aging and aging-associated disorders. Genetic and pharmacological impairment of TRP - KYN metabolism resulted in prolongation of life span in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Drosophila_melanogaster\">Drosophila<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/Animal_model\">models<\/a>.<\/p>\n<p><a href=\"http:\/\/en.wikipedia.org\/wiki\/Minocycline\">Minocycline<\/a>, an antibiotic with anti-inflammatory, antioxidant and neuroprotective properties independent of its antibacterial activity, inhibited KYN formation from TRP. Since minocycline is the only <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/04\/the-fda-is-a-destructive-force.php\">FDA approved<\/a> for human use medication with inhibitory effect on TRP - KYN metabolism, we were interested to study minocycline effect on life- and health-spans in Drosophila model. <\/p>\n<p>Minocycline prolonged mean, median and maximum life span of wild-type Oregon Drosophila melanogaster of both genders [and] might be a promising candidate drug for anti-aging intervention. [The] role of TRP - KYN metabolism in the mechanisms of minocycline-effect on life- and health-span might be elucidated by the future assessment of minocycline effects in Drosophila mutants naturally or artificially knockout for genes impacting the key enzymes of KYN pathway of TRP metabolism.<\/i><\/p><\/blockquote>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23185716\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23185716<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.fightaging.org\/archives\/2012\/11\/kynurenine-tryptophan-metabolism-and-fly-longevity.php\">http:\/\/www.fightaging.org\/archives\/2012\/11\/kynurenine-tryptophan-metabolism-and-fly-longevity.php<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metabolism is a very complex set of overlapping mechanisms, feedback loops, and networks of protein interactions. So even if there are only a few core methods of extending life by altering metabolism in a species, we should expect to see &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/kynurenine-tryptophan-metabolism-and-fly-longevity.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043437","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043437"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043437"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043437\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}