{"id":1043423,"date":"2012-11-04T07:50:09","date_gmt":"2012-11-04T07:50:09","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/promoting-remyelination-by-blocking-hyaluronidase\/"},"modified":"2024-08-17T17:04:27","modified_gmt":"2024-08-17T21:04:27","slug":"promoting-remyelination-by-blocking-hyaluronidase-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/promoting-remyelination-by-blocking-hyaluronidase-2.php","title":{"rendered":"Promoting Remyelination by Blocking Hyaluronidase"},"content":{"rendered":"<p><a href=\"http:\/\/en.wikipedia.org\/wiki\/Myelin\">Myelin<\/a> is the material sheathing <a href=\"http:\/\/en.wikipedia.org\/wiki\/Axon\">axons<\/a> in nerve cells. A number of conditions involve loss of myelin, such as <a href=\"http:\/\/en.wikipedia.org\/wiki\/Multiple_sclerosis\">multiple sclerosis (MS)<\/a>, but loss of myelin integrity <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/10\/on-aging-and-myelin.php\">occurs to a lesser degree for all of us as we age<\/a>, and is thought to contribute to the characteristic cognitive decline of later years. Thus research into <a href=\"https:\/\/encrypted.google.com\/search?q=site%3Afightaging.org+myelin\">ways to regenerate myelin sheathing<\/a> has broad potential application and is worth keeping an eye on:<\/p>\n<blockquote><p><i>We have identified a whole new target for drugs that might promote repair of the damaged brain in any <a href=\"http:\/\/en.wikipedia.org\/wiki\/Demyelinating_disease\">disorder in which demyelination occurs<\/a>. Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders.<\/p>\n<p>In 2005, [researchers] discovered that a sugar molecule, called <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hyaluronic_ac\">hyaluronic acid<\/a>, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lesion\">lesions<\/a>. Their findings at the time [suggested] that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_differentiation\">differentiating<\/a> in areas of brain damage. The new study shows that the hyaluronic acid itself does not prevent the differentiation of myelin-forming cells. Rather, breakdown products generated by a specific <a href=\"http:\/\/en.wikipedia.org\/wiki\/Enzyme\">enzyme<\/a> that chews up hyaluronic acid - called a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hyaluronidase\">hyaluronidase<\/a> - contribute to the remyelination failure.<\/p>\n<p>This enzyme is highly elevated in MS patient brain lesions and in the nervous systems of animals with an MS-like disease. The research team [found] that by blocking hyaluronidase activity, they could promote myelin-forming cell differentiation and remyelination in the mice with the MS-like disease. Most significantly, the drug that blocked hyaluronidase activity led to improved nerve cell function. The next step is to develop drugs that specifically target this enzyme.<\/i><\/p><\/blockquote>\n<p><span>Link: <a href=\"http:\/\/www.sciencedaily.com\/releases\/2012\/10\/121031151611.htm\">http:\/\/www.sciencedaily.com\/releases\/2012\/10\/121031151611.htm<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.fightaging.org\/archives\/2012\/11\/promoting-remyelination-by-blocking-hyaluronidase.php\">http:\/\/www.fightaging.org\/archives\/2012\/11\/promoting-remyelination-by-blocking-hyaluronidase.php<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Myelin is the material sheathing axons in nerve cells. A number of conditions involve loss of myelin, such as multiple sclerosis (MS), but loss of myelin integrity occurs to a lesser degree for all of us as we age, and &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/promoting-remyelination-by-blocking-hyaluronidase-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043423","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043423"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043423"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043423\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}