{"id":1043345,"date":"2012-04-29T15:51:48","date_gmt":"2012-04-29T15:51:48","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/rapamycin-and-oxidative-stress-in-adult-stem-cells\/"},"modified":"2024-08-17T17:03:55","modified_gmt":"2024-08-17T21:03:55","slug":"rapamycin-and-oxidative-stress-in-adult-stem-cells","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/rapamycin-and-oxidative-stress-in-adult-stem-cells.php","title":{"rendered":"Rapamycin and Oxidative Stress in Adult Stem Cells"},"content":{"rendered":"<p>Following on from <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/03\/separating-out-the-effects-of-rapamycin.php\">research into the mechanisms of rapamycin<\/a> released earlier this month, here is more on the way it might generate its <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/07\/latelife-administration-of-rapamycin-extends-life-in-mice.php\">benefits to longevity in laboratory mammals<\/a>: \"Balancing quiescence with proliferation is of paramount importance for <a href=\"http:\/\/en.wikipedia.org\/wiki\/Adult_stem_cell\">adult stem cells<\/a> in order to avoid hyperproliferation and cell depletion. In some models, <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/01\/on-stem-cells-and-their-aging-and-potential-rejuvenation.php\">stem cell exhaustion<\/a> may be reversed with the drug rapamycin, which was shown can suppress <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/06\/why-do-we-accumulate-senescent-cells-anyway.php\">cellular senescence<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vitro\">in vitro<\/a> and extend lifespan in animals. We hypothesized that rapamycin increases the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expression<\/a> of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">oxidative stress<\/a> response genes in adult stem cells, and that these gene activities diminish with age. To test our hypothesis, we exposed mice to rapamycin and then examined the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transcriptome\">transcriptome<\/a> of their <a href=\"http:\/\/en.wikipedia.org\/wiki\/Spermatogonial_stem_cell\">spermatogonial stem cells (SSCs)<\/a>. Gene expression <a href=\"http:\/\/en.wikipedia.org\/wiki\/Microarray\">microarray analysis<\/a> revealed that numerous oxidative stress response genes were upregulated upon rapamycin treatment ... When we examined the expression of these genes in 55-week-old wild type SSCs, their levels were significantly reduced compared to 3-week-old SSCs, suggesting that their downregulation is coincident with the aging process in adult stem cells. We conclude that rapamycin-induced stimulation of oxidative stress response genes may promote cellular longevity in SSCs, while a decline in gene expression in aged stem cells could reflect the SSCs' diminished potential to alleviate oxidative stress, a hallmark of aging.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/impactaging.com\/papers\/v4\/n4\/full\/100451.html\">http:\/\/impactaging.com\/papers\/v4\/n4\/full\/100451.html<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Following on from research into the mechanisms of rapamycin released earlier this month, here is more on the way it might generate its benefits to longevity in laboratory mammals: \"Balancing quiescence with proliferation is of paramount importance for adult stem &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/rapamycin-and-oxidative-stress-in-adult-stem-cells.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043345","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043345"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043345"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043345\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}