{"id":1043329,"date":"2011-05-08T15:51:25","date_gmt":"2011-05-08T15:51:25","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/longevity-differences-within-mole-rat-species\/"},"modified":"2024-08-17T17:03:47","modified_gmt":"2024-08-17T21:03:47","slug":"longevity-differences-within-mole-rat-species","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/longevity-differences-within-mole-rat-species.php","title":{"rendered":"Longevity Differences Within Mole-Rat Species"},"content":{"rendered":"<p><a href=\"http:\/\/www.fightaging.org\/archives\/2011\/03\/revisiting-naked-mole-rats-and-their-lack-of-cancer.php\">Long-lived naked mole-rats<\/a> exhibit fairly large systematic differences in longevity within the species, and understanding the mechanisms may point the way to a class of therapies for aging: \"African mole-rats (<a href=\"http:\/\/en.wikipedia.org\/wiki\/Bathyergidae\">Bathyergidae, Rodentia<\/a>) contain several social, cooperatively breeding species with low extrinsic mortality and unusually high longevity. All social bathyergids live in multigenerational families where reproduction is skewed towards a few breeding individuals. Most of their offspring remain as reproductively inactive 'helpers' in their natal families, often for several years. This 'reproductive subdivision' of mole-rat societies might be of interest for ageing research, as in at least one social bathyergid (<a href=\"http:\/\/en.wikipedia.org\/wiki\/Fukomys_anselli\">Ansell's mole-rats Fukomys anselli<\/a>), breeders have been shown to age significantly slower than non-breeders. These animals thus provide excellent conditions for studying the <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/10\/is-epigenetic-disarray-a-cause-of-aging.php\">epigenetics of senescence<\/a> by comparing divergent longevities within the same <a href=\"http:\/\/en.wikipedia.org\/wiki\/Genotype\">genotypes<\/a> without the inescapable short-comings of inter-species comparisons. It has been claimed that many if not all social mole-rat species may have evolved similar ageing patterns, too. However, this remains unclear on account of the scarcity of reliable datasets on the subject. We therefore analyzed a 20-year breeding record of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Fukomys_mechowii\">Giant mole-rats Fukomys mechowii<\/a>, another social bathyergid species. We found that breeders indeed lived significantly longer than helpers (ca. 1.5 - 2.2fold depending on the sex), irrespective of social rank or other potentially confounding factors.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0018757\">http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0018757<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Long-lived naked mole-rats exhibit fairly large systematic differences in longevity within the species, and understanding the mechanisms may point the way to a class of therapies for aging: \"African mole-rats (Bathyergidae, Rodentia) contain several social, cooperatively breeding species with low &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/longevity-differences-within-mole-rat-species.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043329","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043329"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043329"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043329\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}