{"id":1043206,"date":"2011-06-12T16:06:03","date_gmt":"2011-06-12T16:06:03","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/measuring-the-better-immune-system-of-centenarians\/"},"modified":"2024-08-17T17:02:54","modified_gmt":"2024-08-17T21:02:54","slug":"measuring-the-better-immune-system-of-centenarians","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/measuring-the-better-immune-system-of-centenarians.php","title":{"rendered":"Measuring the Better Immune System of Centenarians"},"content":{"rendered":"<p>It is known that centenarians - <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/06\/more-naive-b-cells-for-centenarians-children.php\">and their immediate families<\/a> - tend to have better <a href=\"http:\/\/en.wikipedia.org\/wiki\/Immune_system\">immune systems<\/a>, a capability that is increasingly important in old age as people become more vulnerable to infections. Here is more research to illustrate this fact: \"Aging is characterized by a progressive alteration of homeostatic mechanisms modulated by environmental and genetic factors. It is <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/02\/inflammation-and-the-damage-of-aging.php\">associated with a pro-inflammatory status<\/a>. In centenarians, an increase of pro-inflammatory <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cytokine\">cytokine<\/a> production balanced by anti-inflammatory immune response that would promote longevity is observed. Cytokine dysregulation is believed to play a key role in the proposed remodeling of the immune-inflammatory responses accompanying old age. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Interleukin_22\">IL-22<\/a> is a pro-inflammatory cytokine belonging to the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Interleukin_10\">IL-10 family<\/a> and represents an important effector molecule of activated [<a href=\"http:\/\/en.wikipedia.org\/wiki\/T_cell\">T cells<\/a>]. We recruited 17 healthy centenarians (4 males, 13 females, range 100-105 years). All ultralongeval subjects were living at home or in a nursing home. Sixteen healthy, sex-matched individuals (4 males, 12 females, range 60-95 years) were also recruited as <a href=\"http:\/\/en.wikipedia.org\/wiki\/Scientific_control\">controls<\/a>. Centenarians displayed significantly higher circulating IL-22 levels compared to control population. It's well known that IL-22 is a pro-inflammatory cytokine produced by activated <a href=\"http:\/\/en.wikipedia.org\/wiki\/T_lymphocyte\">T lymphocytes<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Natural_killer_cell\">NK cells<\/a>. IL-22 stimulates the production of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Acute_phase_reactant\">acute phase reactants<\/a> and promotes the antimicrobial defense. The results of the present study show, for the first time, that there is an increase of IL-22 in healthy centenarians. This pro-inflammatory condition probably is protective against infection, promoting the longevity of these subjects.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21640395\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21640395<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is known that centenarians - and their immediate families - tend to have better immune systems, a capability that is increasingly important in old age as people become more vulnerable to infections. Here is more research to illustrate this &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/measuring-the-better-immune-system-of-centenarians.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043206","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043206"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043206"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043206\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}