{"id":1043148,"date":"2010-04-14T08:22:36","date_gmt":"2010-04-14T08:22:36","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/wilt-alt-and-zscan4\/"},"modified":"2024-08-17T17:02:26","modified_gmt":"2024-08-17T21:02:26","slug":"wilt-alt-and-zscan4-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/wilt-alt-and-zscan4-2.php","title":{"rendered":"WILT, ALT, and Zscan4"},"content":{"rendered":"<p>From the <a href=\"http:\/\/www.sens.org\/node\/739\">SENS Foundation<\/a>: \"To develop an unbreachable defense against cancer, SENS Foundation is pursuing the <a href=\"http:\/\/www.sens.org\/sens-research\/research-themes\/oncosens\">WILT (Wholebody Interdiction of Lengthening of Telomeres) strategy (OncoSENS)<\/a> of systematically deleting genes essential to the cellular <a href=\"http:\/\/en.wikipedia.org\/wiki\/Telomere\">telomere<\/a>-maintenance mechanisms (TMM) from all <a href=\"http:\/\/en.wikipedia.org\/wiki\/Somatic_cell\">somatic cells<\/a>, while ensuring ongoing tissue repair and maintenance <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/06\/complicating-wilt.php\">through periodic re-seeding of somatic stem-cell pools<\/a> with <a href=\"http:\/\/en.wikipedia.org\/wiki\/Autologous\">autologous<\/a> TMM-deficient cells whose telomeres have been lengthened <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ex_vivo\">ex vivo<\/a>. In addition to the deletion of one or more genes coding for essential element(s) of the telomerase <a href=\"http:\/\/en.wikipedia.org\/wiki\/Holoenzyme\">holoenzyme<\/a>, success will also require the deletion of some essential element of the machinery for the <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/01\/alternative-lengthening-of-telomeres-alt-101.php\">Alternative Lengthening of Telomeres (ALT) phenomenon<\/a>, observed in a minority of cancer cells. Heretofore, the identity of that machinery has been elusive. Yeast cells have the ability to lengthen telomeres through a telomerase-independent mechanism involving telomere recombination, and there has been evidence for some time suggesting that ALT cancers lengthen telomeres through a similar process.\" The article goes on to look in detail at one plausible candidate mechanism for ALT, and how this new knowledge might be incorporated into WILT.<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.sens.org\/node\/739\">http:\/\/www.sens.org\/node\/739<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the SENS Foundation: \"To develop an unbreachable defense against cancer, SENS Foundation is pursuing the WILT (Wholebody Interdiction of Lengthening of Telomeres) strategy (OncoSENS) of systematically deleting genes essential to the cellular telomere-maintenance mechanisms (TMM) from all somatic cells, &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/wilt-alt-and-zscan4-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043148","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043148"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043148"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043148\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}