{"id":1043085,"date":"2011-07-24T15:58:07","date_gmt":"2011-07-24T15:58:07","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/calorie-restriction-slows-dna-methylation-in-the-hippocampus\/"},"modified":"2024-08-17T17:02:01","modified_gmt":"2024-08-17T21:02:01","slug":"calorie-restriction-slows-dna-methylation-in-the-hippocampus","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/calorie-restriction-slows-dna-methylation-in-the-hippocampus.php","title":{"rendered":"Calorie Restriction Slows DNA Methylation in the Hippocampus"},"content":{"rendered":"<p><a href=\"http:\/\/en.wikipedia.org\/wiki\/DNA_methylation\">DNA methylation<\/a> is proposed to <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/06\/towards-dna-methylation-as-a-biomarker-of-age-and-aging.php\">be a good biomarker of aging<\/a>, and here researchers show that <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a> slows the progression of DNA methylation in the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hippocampus\">hippocampus<\/a> - continuing the expected trend of calorie restriction slowing near every identified biological change that occurs with aging: \"Aberrant DNA methylation patterns have been linked to molecular and cellular alterations in the aging brain. Caloric restriction (CR) and <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/05\/update-on-catalase-in-the-mitochondria.php\">upregulation of antioxidants<\/a> have been proposed as interventions to prevent or delay age-related brain pathology. Previously, we have shown in large cohorts of aging mice, that age-related increases in <a href=\"http:\/\/en.wikipedia.org\/wiki\/DNA_methyltransferase\">DNA methyltransferase 3a (Dnmt3a)<\/a> immunoreactivity in the mouse hippocampus were attenuated by CR, but not by <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_expression\">overexpression<\/a> of <a href=\"http:\/\/en.wikipedia.org\/wiki\/SOD1\">superoxide dismutase 1 (SOD1)<\/a>. Here, we investigated age-related alterations of 5-methylcytidine (5-mC), a marker of DNA methylation levels, in a hippocampal subregion-specific manner. Examination of 5-mC immunoreactivity in 12- and 24-month-old wild type (WT) mice on control diet, mice overexpressing SOD1 on control diet, wild type mice on CR, and SOD1 mice on CR, indicated an age-related increase in 5-mC immunoreactivity in the hippocampal <a href=\"http:\/\/en.wikipedia.org\/wiki\/Dentate_gyrus\">dentate gyrus<\/a>, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hippocampus_anatomy\">CA3, and CA1-2 regions<\/a>, which was prevented by CR but not by SOD1 overexpression. ... These findings suggest a crucial role for DNA methylation in hippocampal aging and in the mediation of the beneficial effects of CR on aging.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21764481\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21764481<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA methylation is proposed to be a good biomarker of aging, and here researchers show that calorie restriction slows the progression of DNA methylation in the hippocampus - continuing the expected trend of calorie restriction slowing near every identified biological &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/calorie-restriction-slows-dna-methylation-in-the-hippocampus.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043085","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043085"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043085"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043085\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}