{"id":1043077,"date":"2011-05-01T15:51:50","date_gmt":"2011-05-01T15:51:50","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/a-german-interview-with-aubrey-de-grey\/"},"modified":"2024-08-17T17:01:58","modified_gmt":"2024-08-17T21:01:58","slug":"a-german-interview-with-aubrey-de-grey","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-german-interview-with-aubrey-de-grey.php","title":{"rendered":"A German Interview with Aubrey de Grey"},"content":{"rendered":"<p>A translated interview with <a href=\"http:\/\/www.sens.org\">SENS Foundation<\/a> co-founder <a href=\"http:\/\/en.wikipedia.org\/wiki\/Aubrey_de_Grey\">Aubrey de Grey<\/a>: \"I have identified seven types of damage [that cause aging]. In five cases we can repair the damage in my opinion, by replacing irreversibly damaged cells by stem cells, or when garbage accumulates, we will remove [it]. In two cases, we need to engage in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_therapy\">gene therapy<\/a>, for example, through new <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrial_DNA\">DNA<\/a> counteract mutations in the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondria<\/a>. ... We should intervene as little as possible in the metabolic pathways themselves. This <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/09\/the-scientific-debate-that-will-determine-how-long-we-all-live.php\">is too complicated<\/a>, we do not know enough yet about it. I prefer the regenerative approach, the repair and maintenance. It is [sufficient] to repair the damage after it occurred. In this way, we do not [need to] understand all the molecular details and how they come about. But we have to intervene before the problems get out of control. ... A simple example is the stiffening of the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Extracellular_matrix\">extracellular matrix<\/a> - this is the fibrous scaffold between cells. The stiffening occurs because certain molecules network with each other. There is a principal [agent], a molecule called [<a href=\"http:\/\/en.wikipedia.org\/wiki\/Glucosepane\">glucosepane<\/a>], which has the largest share of the networking and reinforcement. We must find <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/age-breakers-beyond-alagebrium.php\">a way to break up about two-thirds of them again<\/a>. If we break these reinforcements, it would eliminate about half of the damage. ... I think the probability is about 50 percent, that all of these therapies in 25 years actually show the desired results. The average life span might then be [increased by] about 30 years.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/translate.google.com\/translate?u=http:\/\/www.heise.de\/tr\/artikel\/Muell-entfernen-und-Zellen-erneuern-1230091.html\">http:\/\/translate.google.com\/translate?u=http:\/\/www.heise.de\/tr\/artikel\/Muell-entfernen-und-Zellen-erneuern-1230091.html<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A translated interview with SENS Foundation co-founder Aubrey de Grey: \"I have identified seven types of damage [that cause aging]. In five cases we can repair the damage in my opinion, by replacing irreversibly damaged cells by stem cells, or &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-german-interview-with-aubrey-de-grey.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043077","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043077"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043077"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043077\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}