{"id":1043070,"date":"2012-04-08T15:51:53","date_gmt":"2012-04-08T15:51:53","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/restoring-some-youthful-gene-expression-levels-in-an-aged-liver\/"},"modified":"2024-08-17T17:01:55","modified_gmt":"2024-08-17T21:01:55","slug":"restoring-some-youthful-gene-expression-levels-in-an-aged-liver-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/restoring-some-youthful-gene-expression-levels-in-an-aged-liver-2.php","title":{"rendered":"Restoring Some Youthful Gene Expression Levels in an Aged Liver"},"content":{"rendered":"<p>An interesting experiment, especially when compared with work on brain aging that <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/04\/can-neural-stem-cells-address-cognitive-decline.php\">focuses on levels of cell proliferation<\/a>: \"During the past decade, it has become increasingly clear that <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/11\/the-mouse-agemap.php\">consistent changes in the levels of expression of a small cohort of genes<\/a> accompany the aging of mammalian tissues. In many cases, these changes have been shown to generate features that are characteristic of the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Senescence\">senescent phenotype<\/a>. Previously, a small pilot study indicated that some of these changes might be reversed in rat liver, if the liver cells became <a href=\"http:\/\/en.wikipedia.org\/wiki\/Malignancy\">malignant<\/a> and were proliferating. The present study has tested the hypothesis that inducing <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cell_proliferation\">proliferation<\/a> in old rat liver can reset the levels of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expression<\/a> of these age-related genes to that observed in young tissue. A <a href=\"http:\/\/en.wikipedia.org\/wiki\/Microarray\">microarray approach<\/a> was used to identify genes that exhibited the greatest changes in their expression during aging. The levels of expression of these markers were then examined in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transcriptome\">transcriptomes<\/a> of both proliferating <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hepatoma\">hepatomas<\/a> from old animals and old rat liver lobes that had <a href=\"http:\/\/en.wikipedia.org\/wiki\/Liver#Regeneration\">regenerated after partial hepatectomy<\/a> but were again quiescent. We have found evidence that over 20% of the aging-related genes had their levels of expression reset to young levels by stimulating proliferation, even in cells that had undergone a limited number of cell cycles and then become quiescent again. Moreover, our network analysis [may] provide insights into mechanisms involved in longevity and regeneration that are distinct from cancer.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22477361\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22477361<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An interesting experiment, especially when compared with work on brain aging that focuses on levels of cell proliferation: \"During the past decade, it has become increasingly clear that consistent changes in the levels of expression of a small cohort of &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/restoring-some-youthful-gene-expression-levels-in-an-aged-liver-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043070","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043070"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043070"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043070\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}