{"id":1043058,"date":"2011-07-31T15:57:10","date_gmt":"2011-07-31T15:57:10","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/aerobic-fitness-improves-the-aging-immune-system\/"},"modified":"2024-08-17T17:01:50","modified_gmt":"2024-08-17T21:01:50","slug":"aerobic-fitness-improves-the-aging-immune-system","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/aerobic-fitness-improves-the-aging-immune-system.php","title":{"rendered":"Aerobic Fitness Improves the Aging Immune System"},"content":{"rendered":"<p>Another reason to exercise: \"<a href=\"http:\/\/www.fightaging.org\/archives\/2006\/12\/when-and-how-does-the-decay-of-your-immune-system.php\">Senescent T-cells accumulate with age<\/a>, lowering the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Naive_T_cell\">naive T-cell<\/a> repertoire and increasing host infection risk. As this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (<a href=\"http:\/\/en.wikipedia.org\/wiki\/VO2_max\">VO(2max)<\/a>) and the age-related accumulation of senescent T-cells. Blood lymphocytes from 102 healthy males (18-61yr) were analyzed for [marker] surface expression on <a href=\"http:\/\/en.wikipedia.org\/wiki\/CD4\">CD4+<\/a> and CD8+ T-cells ... Advancing age (yr) was positively associated with the proportion (%) of senescent [and] <a href=\"http:\/\/en.wikipedia.org\/wiki\/CD8\">CD8+<\/a> T-cells and inversely associated with naive CD4+ and CD8+ T-cells. VO(2max) was inversely associated with senescent CD4+ and CD8+. Strikingly, age was no longer associated with the proportions of senescent or naive T-cells after adjusting for VO(2max), while the association between VO(2max) and these T-cell subsets withstood adjustment for age, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Body_mass_index\">BMI<\/a> and percentage body fat. Ranking participants by age-adjusted VO(2max) revealed that the highest tertile had had 17% more naive CD8+ T-cells and 57% and 37% less senescent CD4+ and CD8+ T-cells, respectively, compared to the lowest tertile. This is the first study to show that aerobic fitness is associated with a lower age-related accumulation of senescent T-cells, highlighting the beneficial effects of maintaining a physically active lifestyle on the aging <a href=\"http:\/\/en.wikipedia.org\/wiki\/Immune_system\">immune system<\/a>.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21784146\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21784146<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Another reason to exercise: \"Senescent T-cells accumulate with age, lowering the naive T-cell repertoire and increasing host infection risk. As this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (VO(2max)) and &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/aerobic-fitness-improves-the-aging-immune-system.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043058","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043058"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043058"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043058\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}