{"id":1043047,"date":"2012-03-04T16:52:36","date_gmt":"2012-03-04T16:52:36","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/more-support-for-the-membrane-pacemaker-hypothesis-of-aging\/"},"modified":"2024-08-17T17:01:46","modified_gmt":"2024-08-17T21:01:46","slug":"more-support-for-the-membrane-pacemaker-hypothesis-of-aging","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/more-support-for-the-membrane-pacemaker-hypothesis-of-aging.php","title":{"rendered":"More Support for the Membrane Pacemaker Hypothesis of Aging"},"content":{"rendered":"<p>The <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/05\/comparative-biology-and-the-membrane-pacemaker-hypothesis.php\">membrane pacemaker hypothesis<\/a> suggests that longevity differences between species are largely determined by the resistance to oxidative damage exhibited by important <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cell_membrane\">cell membranes<\/a> - such as <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">those in mitochondria<\/a>. Here is some evidence to suggest that this holds up within a species too: \"Membrane unsaturation plays an important role in the aging process and the determination of inter-species animal longevity. Furthermore, the accumulation of oxidation-derived molecular damage to cellular components particularly in the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nervous_system\">nervous<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Immune_system\">immune systems<\/a> over time leads to <a href=\"http:\/\/en.wikipedia.org\/wiki\/Homeostasis\">homeostasis<\/a> loss, which highly influences age-related <a href=\"http:\/\/en.wikipedia.org\/wiki\/Morbidity\">morbidity<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mortality_rate\">mortality<\/a>. In this context, it is of great interest to know and discern the degree of membrane unsaturation and the steady-state levels of oxidative damage in both physiological systems from long-lived subjects. In the present work, adult (28?\u00b1?4 weeks), old (76?\u00b1?4 weeks) and exceptionally old (128?\u00b1?4 weeks) <a href=\"http:\/\/en.wikipedia.org\/wiki\/BALB\/c\">BALB\/c female mice<\/a> were used. Brain and spleen were analysed for membrane fatty acid composition and specific markers of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">protein oxidation<\/a>, <a href=\"http:\/\/www.sens.org\/node\/181\">glycoxidation<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lipid_peroxidation\">lipoxidation<\/a> damage ... The results showed significantly [higher membrane resistance to <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lipid_peroxidation\">lipid peroxidation<\/a> and lower lipoxidation-derived molecular damage brain and spleen in] exceptionally old animals when compared to old specimens ... In addition, the higher levels of the glycoxidation-derived marker observed in exceptionally old animals, as well as in adult mice, could be considered as a good indicator of a better bioenergetic state of these animals when compared to the old group. In conclusion, low lipid oxidation susceptibility and maintenance of adult-like protein lipoxidative damage could be key mechanisms for longevity achievement.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22367548\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22367548<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The membrane pacemaker hypothesis suggests that longevity differences between species are largely determined by the resistance to oxidative damage exhibited by important cell membranes - such as those in mitochondria. Here is some evidence to suggest that this holds up &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/more-support-for-the-membrane-pacemaker-hypothesis-of-aging.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043047","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043047"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043047"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043047\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}