{"id":1043017,"date":"2010-05-18T08:18:15","date_gmt":"2010-05-18T08:18:15","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/testing-the-mitochondrial-free-radical-theory-of-aging\/"},"modified":"2024-08-17T17:01:33","modified_gmt":"2024-08-17T21:01:33","slug":"testing-the-mitochondrial-free-radical-theory-of-aging","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/testing-the-mitochondrial-free-radical-theory-of-aging.php","title":{"rendered":"Testing the Mitochondrial Free Radical Theory of Aging"},"content":{"rendered":"<p>An open access paper from <a href=\"http:\/\/www.impactaging.com\/papers\/v2\/n4\/full\/100137.html\">Impact Aging<\/a>: \"The <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">Mitochondrial Free Radical Theory of Aging (MFRTA)<\/a> is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondrial<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/Rreactiv\">Reactive Oxygen Species (mtROS)<\/a> than short-lived individuals or species; a decrease in mtROS production will increase lifespan; and an increase in mtROS production will decrease lifespan. It is possible to add a further fourth prediction: if ROS is controlling longevity separating these parameters through <a href=\"http:\/\/en.wikipedia.org\/wiki\/Natural_selection\">selection<\/a> would be impossible. These predictions have been tested in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Drosophila_melanogaster\">Drosophila melanogaster<\/a>.\" Where I think the researchers go wrong here lies in not accounting for how differences in mitochondrial composition might affect the level of damage caused by a given amount of ROS. There is a strong argument that species life span differences have a lot to do with <a href=\"http:\/\/www.longevitymeme.org\/news\/view_news_item.cfm?news_\">how resilient mitochondria are to damage<\/a>. But read the paper anyway; it's a good introduction to thinking about the mitochondrial free radical theory of aging.<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.impactaging.com\/papers\/v2\/n4\/full\/100137.html\">http:\/\/www.impactaging.com\/papers\/v2\/n4\/full\/100137.html<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An open access paper from Impact Aging: \"The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/testing-the-mitochondrial-free-radical-theory-of-aging.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043017","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043017"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043017"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043017\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}