{"id":1043002,"date":"2011-08-14T15:56:32","date_gmt":"2011-08-14T15:56:32","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/investigating-the-indy-gene\/"},"modified":"2024-08-17T17:01:27","modified_gmt":"2024-08-17T21:01:27","slug":"investigating-the-indy-gene","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/investigating-the-indy-gene.php","title":{"rendered":"Investigating the INDY Gene"},"content":{"rendered":"<p>The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Indy_(gene)\">I'm Not Dead Yet (INDY) gene<\/a> is one of the earlier longevity genes discovered by researchers in course of investigating the effects of <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a>. Here is a recent update: \"It is known that excess calorie consumption leads to obesity, <a href=\"http:\/\/en.wikipedia.org\/Insulin_resistance\">insulin resistance<\/a> and increased mortality, whereas calorie restriction reduces accumulation of body fat and improves cellular energy balance and insulin action - reversing obesity and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Type_2_diabetes\">type 2 diabetes<\/a>, delaying the aging process, and prolonging life in primates and many other species. It has also been shown in the past that reduced expression of the so-called 'INDY' gene in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Drosophila_melanogaster\">D. Melanogaster<\/a> flies and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Caenorhabditis_elegans\">C. elegans<\/a> worms promotes longevity in a manner similar to calorie restriction. But until now, the cellular mechanism by which this happens was unknown. [Researchers] generated a mouse with the so-called 'INDY' gene deleted. Loss of the gene altered chemical levels in the cellular signaling network in a way that improved <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondrial action<\/a> in the liver, metabolism of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Fatty_ac\">fatty acids<\/a>, and cellular energy transport. Overall, these traits protected the mice from diet-related accumulation of body fat and insulin resistance that evolve, as we age, into type 2 diabetes. Discovering how deletion of the INDY gene would impact mitochondrial metabolism in the liver was key, because that is the main organ where the INDY gene does its work.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/opac.yale.edu\/news\/article.aspx?id=8772\">http:\/\/opac.yale.edu\/news\/article.aspx?id=8772<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The I'm Not Dead Yet (INDY) gene is one of the earlier longevity genes discovered by researchers in course of investigating the effects of calorie restriction. Here is a recent update: \"It is known that excess calorie consumption leads to &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/investigating-the-indy-gene.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1043002","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043002"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1043002"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1043002\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1043002"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1043002"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1043002"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}