{"id":1042917,"date":"2012-04-15T15:51:36","date_gmt":"2012-04-15T15:51:36","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/explaining-how-altered-igf-1-signaling-extends-life\/"},"modified":"2024-08-17T17:00:52","modified_gmt":"2024-08-17T21:00:52","slug":"explaining-how-altered-igf-1-signaling-extends-life","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/explaining-how-altered-igf-1-signaling-extends-life.php","title":{"rendered":"Explaining How Altered IGF-1 Signaling Extends Life"},"content":{"rendered":"<p>Signs of progress in understanding the mechanisms of induced longevity through <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/10\/some-papers-on-igf1-and-insulin-in-aging.php\">altered insulin\/IGF-1 signaling<\/a> are shown in this paper. This is one of the most-studied class of longevity mutations in lower animals, despite there being some debate over <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/12\/cautionary-data-on-igf-1-involvement-in-longevity-in-mammals.php\">whether it is relevant to mammal biochemistry<\/a>. Here, the basic mechanism is <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22482723\">explained as being hormetic<\/a>, centering on the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondria<\/a>: researchers \"elucidate a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Conserved_sequence\">conserved mechanism<\/a> through which reduced insulin-IGF1 signaling activates an <a href=\"http:\/\/en.wikipedia.org\/wiki\/AMP-activated_protein_kinase\">AMP-kinase<\/a>-driven metabolic shift toward oxidative <a href=\"http:\/\/en.wikipedia.org\/wiki\/Proline\">proline<\/a> metabolism. This, in turn, produces an adaptive mitochondrial [<a href=\"http:\/\/en.wikipedia.org\/wiki\/Reactive_oxygen_species\">reactive oxygen species (ROS)<\/a>] signal that extends worm life span. These findings further bolster the concept of <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/07\/on-mitohormesis.php\">mitohormesis<\/a> as a critical component of conserved aging and longevity pathways. ... Impaired insulin and IGF-1 signaling (iIIS) in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Caenorhabditis_elegans\">C. elegans<\/a> <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/05\/more-than-you-ever-wanted-to-know-about-daf-gene-pathways.php\">daf-2 mutants<\/a> extends life span more than 2-fold. Constitutively, iIIS increases mitochondrial activity and reduces reactive oxygen species (ROS) levels. By contrast, acute impairment of daf-2 in adult C. elegans reduces glucose uptake and transiently increases ROS. Consistent with the concept of mitohormesis, this ROS signal causes an adaptive response by inducing ROS defense <a href=\"http:\/\/en.wikipedia.org\/wiki\/Enzyme\">enzymes<\/a>, culminating in ultimately reduced ROS levels despite increased mitochondrial activity. <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/05\/exercise-reactive-oxygen-species-and-antioxidants.php\">Inhibition of this ROS signal by antioxidants<\/a> reduces iIIS-mediated longevity by up to 60%. ... IIIS upregulates mitochondrial L-proline <a href=\"http:\/\/en.wikipedia.org\/wiki\/Catabolism\">catabolism<\/a>, and impairment of the latter impairs the life span-extending capacity of iIIS while L-proline supplementation extends C. elegans life span. Taken together, iIIS promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22482728\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22482728<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Signs of progress in understanding the mechanisms of induced longevity through altered insulin\/IGF-1 signaling are shown in this paper. This is one of the most-studied class of longevity mutations in lower animals, despite there being some debate over whether it &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/explaining-how-altered-igf-1-signaling-extends-life.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042917","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042917"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042917"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042917\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}