{"id":1042885,"date":"2011-09-18T16:02:25","date_gmt":"2011-09-18T16:02:25","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/hormesis-cell-death-and-aging\/"},"modified":"2024-08-17T17:00:40","modified_gmt":"2024-08-17T21:00:40","slug":"hormesis-cell-death-and-aging","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/hormesis-cell-death-and-aging.php","title":{"rendered":"Hormesis, Cell Death, and Aging"},"content":{"rendered":"<p>A short open access paper: \"<a href=\"http:\/\/en.wikipedia.org\/wiki\/Hormesis\">Hormesis<\/a> (a neologism coined from the ancient Greek term horm\u00e1ein, which literally means 'to set in motion, impel, urge on') describes a favorable biological response to harmless doses of toxins and other stressors. Hormesis-stimulating compounds initiate an adaptive stress response that renders cells\/organisms resistant against high (and normally harmful) doses of the same agent. On the theoretical level, hormesis may constitute (one of) the mechanisms that allows stressed cells to avoid <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_senescence\">senescence<\/a> and death, and hence might have some impact on the (patho)physiology of aging. Thus, measures that reportedly prolong the healthy lifespan of multiple species, such as <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">caloric restriction<\/a> and the administration of <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/02\/resveratrol-is-weak-medicine-and-its-well-past-time-to-move-on.php\">resveratrol<\/a>, may do so by inducing a hormetic response ... [Hormesis] is best represented by <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ischemia\">ischemic<\/a> preconditioning, the situation in which short ischemic episodes protect the brain and the heart against prolonged shortage of oxygen and nutrients. Many molecules that cause cell death <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/03\/all-roads-lead-to-autophagy.php\">also elicit autophagy<\/a>, a cytoprotective mechanism relying on the digestion of potentially harmful intracellular structures, notably <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondria<\/a>. When high doses of these agents are employed, cells undergo <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion#Outer_membrane\">mitochondrial outer membrane<\/a> permeabilization and die. In contrast, low doses of such cytotoxic agents can activate hormesis in several paradigms, and this may explain the lifespan-prolonging potential of autophagy inducers including resveratrol and caloric restriction.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/impactaging.com\/papers\/v3\/n9\/full\/100380.html\">http:\/\/impactaging.com\/papers\/v3\/n9\/full\/100380.html<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A short open access paper: \"Hormesis (a neologism coined from the ancient Greek term horm\u00e1ein, which literally means 'to set in motion, impel, urge on') describes a favorable biological response to harmless doses of toxins and other stressors. Hormesis-stimulating compounds &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/hormesis-cell-death-and-aging.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042885","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042885"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042885"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}