{"id":1042875,"date":"2012-03-04T16:51:46","date_gmt":"2012-03-04T16:51:46","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/another-longevity-gene-in-nematodes\/"},"modified":"2024-08-17T17:00:36","modified_gmt":"2024-08-17T21:00:36","slug":"another-longevity-gene-in-nematodes","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/another-longevity-gene-in-nematodes.php","title":{"rendered":"Another Longevity Gene in Nematodes"},"content":{"rendered":"<p>A mere 40% extension of life span in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nematode\">nematode worms<\/a> via a novel method is a part of the general background noise of aging research nowadays: \"The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Wnt_signaling_pathway#Planar_cell_polarity\">planar cell polarity (PCP) pathway<\/a> is highly <a href=\"http:\/\/en.wikipedia.org\/wiki\/Conserved_sequence\">conserved<\/a> from <a href=\"http:\/\/en.wikipedia.org\/wiki\/Drosophila\">Drosophila<\/a> to humans and a PCP-like pathway has recently been described in the nematode <a href=\"http:\/\/en.wikipedia.org\/wiki\/Caenorhabditis_elegans\">Caenorhabditis elegans<\/a>. The developmental function of this pathway is to coordinate the orientation of cells or structures within the plane of an <a href=\"http:\/\/en.wikipedia.org\/wiki\/Epithelium\">epithelium<\/a> or to organize cell-cell intercalation required for correct <a href=\"http:\/\/en.wikipedia.org\/wiki\/Morphogenesis\">morphogenesis<\/a>. Here, we describe a novel role of <a href=\"http:\/\/www.wormbase.org\/db\/gene\/gene?name=WBGene00015171;\">VANG-1<\/a>, the only C. elegans <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ortholog\">ortholog<\/a> of the conserved PCP component <a href=\"http:\/\/www.sdbonline.org\/fly\/dbzhnsky\/strabis1.htm\">Strabismus\/Van Gogh<\/a>. We show that two <a href=\"http:\/\/en.wikipedia.org\/wiki\/Allele\">alleles<\/a> of vang-1 and depletion of the protein by <a href=\"http:\/\/en.wikipedia.org\/wiki\/RNA_interference\">RNAi<\/a> cause an increase of mean life span up to 40%. Consistent with the longevity <a href=\"http:\/\/en.wikipedia.org\/wiki\/Phenotype\">phenotype<\/a> vang-1 animals also show enhanced resistance to thermal- and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">oxidative stress<\/a> and decreased <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lipofuscin\">lipofuscin<\/a> accumulation. In addition, vang-1 mutants show defects like reduced brood size, decreased ovulation rate and prolonged reproductive span, which are also related to [longevity-enhancing genes]. The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Germline\">germline<\/a>, but not the intestine or <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neuron\">neurons<\/a>, seems to be the primary site of vang-1 function. Life span extension in vang-1 mutants depends on the <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/10\/some-papers-on-igf1-and-insulin-in-aging.php\">insulin\/IGF-1-like<\/a> receptor <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/05\/more-than-you-ever-wanted-to-know-about-daf-gene-pathways.php\">DAF-2 and DAF-16\/FoxO transcription factor<\/a>.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0032183\">http:\/\/dx.doi.org\/10.1371\/journal.pone.0032183<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A mere 40% extension of life span in nematode worms via a novel method is a part of the general background noise of aging research nowadays: \"The planar cell polarity (PCP) pathway is highly conserved from Drosophila to humans and &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/another-longevity-gene-in-nematodes.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042875","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042875"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042875"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042875\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}