{"id":1042849,"date":"2011-10-02T16:08:33","date_gmt":"2011-10-02T16:08:33","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/continued-work-on-autophagy-and-rapamycin\/"},"modified":"2024-08-17T17:00:25","modified_gmt":"2024-08-17T21:00:25","slug":"continued-work-on-autophagy-and-rapamycin","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/continued-work-on-autophagy-and-rapamycin.php","title":{"rendered":"Continued Work on Autophagy and Rapamycin"},"content":{"rendered":"<p><a href=\"http:\/\/www.fightaging.org\/archives\/2009\/07\/latelife-administration-of-rapamycin-extends-life-in-mice.php\">Rapamycin<\/a> is known to extend life in mice, so researchers are looking into the mechanisms and possible uses as a therapy for age-related diseases. \"Previous studies have shown that inducing <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/05\/autophagy.php\">autophagy<\/a> ameliorates early cognitive deficits associated with the build-up of soluble <a href=\"http:\/\/en.wikipedia.org\/wiki\/Beta_amylo\">amyloid-? (A?)<\/a>. However, the effects of inducing autophagy on <a href=\"http:\/\/en.wikipedia.org\/wiki\/Amylo\">plaques<\/a> and <a href=\"http:\/\/www.fightaging.org\/archives\/2005\/07\/alzheimers-tau-1.php\">tangles<\/a> are yet to be determined. While soluble A? and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Tau_protein\">tau<\/a> represent toxic species in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alzheimer's_disease\">Alzheimer's disease (AD)<\/a> pathogenesis, there is well documented evidence that plaques and tangles also are detrimental to normal brain function. Thus, it is critical to assess the effects of inducing autophagy in an <a href=\"http:\/\/en.wikipedia.org\/wiki\/Animal_model\">animal model<\/a> with established plaques and tangles. Here we show that rapamycin, when given prophylactically to 2-month-old 3xTg-AD mice throughout their life, induces autophagy and significantly reduces plaques, tangles and cognitive deficits. In contrast, inducing autophagy in 15-month-old 3xTg-AD mice, which have established plaques and tangles, has no effects on AD-like pathology and cognitive deficits. In conclusion, we show that autophagy induction via rapamycin may represent a valid therapeutic strategy in AD when administered early in the disease progression.\" This research is actually fairly indicative of the field as a whole: mechanisms that are potentially modestly useful as ways to slow aging across life are forced into consideration as late-stage therapies only. This happens because <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/07\/the-problem-illustrated.php\">regulators will not permit commercialization of ways to treat aging<\/a> in otherwise healthy people - they only permit treatments for named diseases. So progress is necessarily sub-optimal where it is permitted at all.<\/p>\n<p><span><a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0025416\">http:\/\/dx.doi.org\/10.1371\/journal.pone.0025416<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapamycin is known to extend life in mice, so researchers are looking into the mechanisms and possible uses as a therapy for age-related diseases. \"Previous studies have shown that inducing autophagy ameliorates early cognitive deficits associated with the build-up of &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/continued-work-on-autophagy-and-rapamycin.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042849","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042849"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042849"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042849\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}