{"id":1042822,"date":"2012-07-15T15:49:48","date_gmt":"2012-07-15T15:49:48","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/investigating-the-mechanisms-of-rheumatoid-arthritis\/"},"modified":"2024-08-17T17:00:14","modified_gmt":"2024-08-17T21:00:14","slug":"investigating-the-mechanisms-of-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/investigating-the-mechanisms-of-rheumatoid-arthritis.php","title":{"rendered":"Investigating the Mechanisms of Rheumatoid Arthritis"},"content":{"rendered":"<p>Researchers examine possible molecular mechanisms for <a href=\"http:\/\/en.wikipedia.org\/wiki\/Rheumatoid_arthritis\">rheumatoid arthritis<\/a> in a paper published earlier in the year: \"Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory and destructive joint disorder that affects tens of millions of people worldwide. Normal healthy joints maintain a balance between the synthesis of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Extracellular_matrix\">extracellular matrix (ECM)<\/a> molecules and the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Proteolysis\">proteolytic degradation<\/a> of damaged ones. In the case of RA, this balance is shifted toward matrix destruction due to increased production of cleavage <a href=\"http:\/\/en.wikipedia.org\/wiki\/Enzyme\">enzymes<\/a> and the presence of (autoimmune) <a href=\"http:\/\/en.wikipedia.org\/wiki\/Immunoglobulin\">immunoglobulins<\/a> resulting from an inflammation induced immune response. Herein we demonstrate that a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Polyclonal_antibodies\">polyclonal antibody<\/a> against the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Proteoglycan\">proteoglycan<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/Biglycan\">biglycan (BG)<\/a> causes tissue destruction that may be analogous to that of RA affected tissues. The effect of the antibody is more potent than harsh chemical and\/or enzymatic treatments designed to mimic arthritis-like fibril de-polymerization. ... The specific <a href=\"http:\/\/en.wikipedia.org\/wiki\/Antigen\">antigen<\/a> that causes the RA immune response has not yet been identified, although possible candidates have been proposed, including <a href=\"http:\/\/en.wikipedia.org\/wiki\/Collagen\">collagen types I and II<\/a>, and proteoglycans (PG's) such as biglycan. We speculate that the initiation of RA associated tissue destruction <a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vivo\">in vivo<\/a> may involve a similar non-enzymatic decomposition of collagen fibrils via the immunoglobulins themselves that we observe here <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ex_vivo\">ex vivo<\/a>.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0032241\">http:\/\/dx.doi.org\/10.1371\/journal.pone.0032241<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers examine possible molecular mechanisms for rheumatoid arthritis in a paper published earlier in the year: \"Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory and destructive joint disorder that affects tens of millions of people worldwide. Normal healthy joints maintain &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/investigating-the-mechanisms-of-rheumatoid-arthritis.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042822","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042822"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042822"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042822\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}