{"id":1042809,"date":"2011-10-16T15:58:00","date_gmt":"2011-10-16T15:58:00","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/age-levels-correlate-with-cognitive-decline\/"},"modified":"2024-08-17T17:00:09","modified_gmt":"2024-08-17T21:00:09","slug":"age-levels-correlate-with-cognitive-decline","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/age-levels-correlate-with-cognitive-decline.php","title":{"rendered":"AGE Levels Correlate With Cognitive Decline"},"content":{"rendered":"<p>An <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/age-breakers-beyond-alagebrium.php\">accumulation of advanced glycation endproducts (AGEs)<\/a> is one of the changes thought to be a root cause of aging. The research quoted below is only a correlation, but there is <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/07\/a-good-glycation-review.php\">plenty more where this came from<\/a> to back up the viewpoint of AGEs as a contributing cause of aging: \"Several studies report that diabetes increases risk of cognitive impairment; some have hypothesized that <a href=\"http:\/\/en.wikipedia.org\/wiki\/Advanced_glycation_end-product\">advanced glycation end products (AGEs)<\/a> underlie this association. AGEs are <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cross-link\">cross-linked<\/a> products that result from reactions between glucose and proteins. Little is known about the association between peripheral AGE concentration and cognitive aging. ... We prospectively studied 920 elders without <a href=\"http:\/\/en.wikipedia.org\/wiki\/Dementia\">dementia<\/a>, 495 with <a href=\"http:\/\/en.wikipedia.org\/wiki\/Diabetes\">diabetes<\/a> and 425 with normal glucose (mean age 74.0 years). Using mixed models, we examined baseline AGE concentration, measured with urine <a href=\"http:\/\/en.wikipedia.org\/wiki\/Pentosidine\">pentosidine<\/a> and analyzed as <a href=\"http:\/\/en.wiktionary.org\/wiki\/tertile\">tertile<\/a>, and performance on the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mini%E2%80%93mental_state_examination\">Modified Mini-Mental State Examination (3MS)<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Digit_symbol_substitution_test\">Digit Symbol Substitution Test (DSST)<\/a> at baseline and repeatedly over 9 years. ... Older adults with high pentosidine level had worse baseline DSST score but not different 3MS score. On both tests, there was a more pronounced 9-year decline in those with high and mid pentosidine level compared to those in the lowest tertile ... [Thus] high peripheral AGE level is associated with greater cognitive decline in older adults with and without diabetes.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21900628\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21900628<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An accumulation of advanced glycation endproducts (AGEs) is one of the changes thought to be a root cause of aging. The research quoted below is only a correlation, but there is plenty more where this came from to back up &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/age-levels-correlate-with-cognitive-decline.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042809","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042809"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042809"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042809\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}