{"id":1042776,"date":"2011-10-23T15:57:52","date_gmt":"2011-10-23T15:57:52","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/another-look-at-epigenetic-inheritance-of-longevity\/"},"modified":"2024-08-17T16:59:55","modified_gmt":"2024-08-17T20:59:55","slug":"another-look-at-epigenetic-inheritance-of-longevity","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/another-look-at-epigenetic-inheritance-of-longevity.php","title":{"rendered":"Another Look at Epigenetic Inheritance of Longevity"},"content":{"rendered":"<p>Researchers investigating <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a> have noticed that its effects on longevity can be inherited through <a href=\"http:\/\/en.wikipedia.org\/wiki\/Epigenetics\">epigenetic<\/a> variations - which makes sense, given the reasons why individual longevity variations in response to available food evolved in the first place. If it is advantageous for a given individual at a given time to shift metabolism into a mode that allows it to live longer due to a decline in available food, then it's probably also advantageous for the children to do that from birth as well: \"The tiny soil-dwelling worms <a href=\"http:\/\/en.wikipedia.org\/wiki\/Caenorhabditis_elegans\">C. elegans<\/a>, when given mutations that make them live longer, transmit that trait even when their progeny don't inherit the life-extending mutations. ... Although much more research remains to be done, the new study raises the tantalizing possibility that if Grandma practiced caloric restriction - which affects the expression of longevity-enhancing genes - her descendants might reap the benefits. The inheritance occurs through \"epigenetics\": alterations not in the coding sequence of <a href=\"http:\/\/en.wikipedia.org\/wiki\/DNA\">DNA<\/a> (those ubiquitous A's, T's, C's, and G's) but in chemical changes that affect whether genes are <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expressed<\/a>. ... [A] <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/06\/ash2-another-longevity-gene-in-worms.php\">protein complex called ASH-2<\/a> [alters] <a href=\"http:\/\/en.wikipedia.org\/wiki\/Histone\">histones<\/a> in C. elegans, reconfiguring the histone-DNA complex into an 'open' state that promotes gene expression. Deficiencies in ASH-2 extend the worm's life span by as much as 30 percent. ... [researchers] blocked the three key proteins that make up the ASH-2 complex by mutating their genes. As expected, the worms lived longer - typically, an extra seven days beyond their lab life span of 20. [Researchers] bred the mutated worms with normal worms until their descendants no longer had the mutations. Nevertheless, the progeny still lived longer, as did their own descendants: even though their genes for the key proteins were normal, an epigenetic memory of longevity persisted.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.technologyreview.com\/biomedicine\/38943\/\">http:\/\/www.technologyreview.com\/biomedicine\/38943\/<\/a><\/span>\n<\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers investigating calorie restriction have noticed that its effects on longevity can be inherited through epigenetic variations - which makes sense, given the reasons why individual longevity variations in response to available food evolved in the first place. If it &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/another-look-at-epigenetic-inheritance-of-longevity.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042776","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042776"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042776"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042776\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}