{"id":1042745,"date":"2012-07-15T15:50:43","date_gmt":"2012-07-15T15:50:43","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/trehalose-calorie-restriction-and-longevity-in-yeast\/"},"modified":"2024-08-17T16:59:42","modified_gmt":"2024-08-17T20:59:42","slug":"trehalose-calorie-restriction-and-longevity-in-yeast","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/trehalose-calorie-restriction-and-longevity-in-yeast.php","title":{"rendered":"Trehalose, Calorie Restriction, and Longevity in Yeast"},"content":{"rendered":"<p>You might recall that a few years ago, researchers <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/05\/trehalose-and-nematode-worm-longevity.php\">extended life in nematode worms<\/a> by feeding them <a href=\"http:\/\/en.wikipedia.org\/wiki\/Trehalose\">trehalose<\/a>. Here, scientists link normal abundances of trehalose in yeast cells with the longevity induced by <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a>: \"Our recent investigation of how a lifespan-extending caloric restriction (CR) diet alters the metabolic history of chronologically aging yeast suggested that their longevity is programmed by the level of metabolic capacity - including trehalose biosynthesis and degradation - that yeast cells developed prior to entry into quiescence. To investigate whether trehalose <a href=\"http:\/\/en.wikipedia.org\/wiki\/Homeostasis\">homeostasis<\/a> in chronologically aging yeast may play a role in longevity extension by CR, in this study we examined how single-gene-deletion mutations affecting trehalose biosynthesis and degradation impact (1) the age-related dynamics of changes in trehalose concentration; (2) yeast chronological lifespan under CR conditions; (3) the chronology of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">oxidative protein damage<\/a>, intracellular <a href=\"http:\/\/en.wikipedia.org\/wiki\/Reactive_oxygen_species\">ROS<\/a> level and protein aggregation; and (4) the timeline of thermal inactivation of a protein in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Heat_shock_protein\">heat-shocked<\/a> yeast cells and its subsequent reactivation in yeast returned to low temperature. Our data imply that CR extends yeast chronological lifespan in part by altering a pattern of age-related changes in trehalose concentration. We outline a model for molecular mechanisms underlying the essential role of trehalose in defining yeast longevity by modulating protein folding, misfolding, unfolding, refolding, oxidative damage, solubility, and aggregation throughout lifespan.\" Trehelose stimulates <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/05\/autophagy.php\">autophagy<\/a> in higher animals, the all-important set of mechanisms that recycle damaged cell components, so one would expect it to be beneficial there as well.<\/p>\n<p><span>Link: <a href=\"http:\/\/www.frontiersin.org\/Integrative_Physiology\/10.3389\/fphys.2012.00256\/full\">http:\/\/www.frontiersin.org\/Integrative_Physiology\/10.3389\/fphys.2012.00256\/full<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>You might recall that a few years ago, researchers extended life in nematode worms by feeding them trehalose. Here, scientists link normal abundances of trehalose in yeast cells with the longevity induced by calorie restriction: \"Our recent investigation of how &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/trehalose-calorie-restriction-and-longevity-in-yeast.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042745","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042745"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042745"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042745\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}