{"id":1042744,"date":"2012-07-15T15:50:35","date_gmt":"2012-07-15T15:50:35","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/mitochondrial-haplotypes-correlate-with-dementia-risk\/"},"modified":"2024-08-17T16:59:42","modified_gmt":"2024-08-17T20:59:42","slug":"mitochondrial-haplotypes-correlate-with-dementia-risk","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/mitochondrial-haplotypes-correlate-with-dementia-risk.php","title":{"rendered":"Mitochondrial Haplotypes Correlate With Dementia Risk"},"content":{"rendered":"<p>Some <a href=\"http:\/\/en.wikipedia.org\/wiki\/Human_mitochondrial_DNA_haplogroup\">mitochondrial DNA lineages<\/a> are <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/07\/some-people-have-better-mitochondrial-dna-part-ii.php\">objectively better than others<\/a>, as demonstrated by <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/07\/more-on-mitochondrial-haplogroups-and-longevity.php\">correlations with longevity<\/a> in humans. Here is a correlation with <a href=\"http:\/\/en.wikipedia.org\/wiki\/Dementia\">dementia<\/a> risk, which might be superficially explained by a greater ability to power fuel-hungry <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neuron\">neurons<\/a>, or greater resistance to mitochondrial damage over time: \"Mitochondrial dysfunction is a prominent hallmark of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alzheimer's_disease\">Alzheimer's disease (AD)<\/a>. Mitochondrial DNA (mtDNA) damage may be <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">a major cause of abnormal reactive oxidative species production in AD<\/a> or increase neuronal susceptibility to oxidative injury during aging. The purpose of this study was to assess the influence of mtDNA <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nucleic_acid_sequence\">sequence<\/a> variation on clinically significant cognitive impairment and dementia risk in the population-based <a href=\"http:\/\/www.grc.nia.nih.gov\/branches\/ledb\/healthabc\/index.htm\">Health, Aging, and Body Composition (Health ABC) Study<\/a>. We first investigated the role of common <a href=\"http:\/\/en.wikipedia.org\/wiki\/Human_mitochondrial_DNA_haplogroup\">mtDNA haplogroups<\/a> and individual variants on dementia risk and 8-year change on the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mini%E2%80%93mental_state_examination\">Modified Mini-Mental State Examination (3MS)<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Digit_symbol_substitution_test\">Digit Symbol Substitution Test (DSST)<\/a> among 1,631 participants of European genetic ancestry. Participants were free of dementia at baseline and incidence was determined in 273 cases from hospital and medication records over 10-12 follow-up years. Participants from haplogroup T had a statistically significant increased risk of developing dementia and haplogroup J participants experienced a statistically significant 8-year decline in 3MS, both compared with common haplogroup H. [Other variants were] associated with a significant decline in DSST score [or] 3MS score.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22785396\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22785396<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some mitochondrial DNA lineages are objectively better than others, as demonstrated by correlations with longevity in humans. Here is a correlation with dementia risk, which might be superficially explained by a greater ability to power fuel-hungry neurons, or greater resistance &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/mitochondrial-haplotypes-correlate-with-dementia-risk.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042744","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042744"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042744"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042744\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}