{"id":1042719,"date":"2011-11-06T16:59:10","date_gmt":"2011-11-06T16:59:10","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/a-review-of-bioartificial-lung-engineering\/"},"modified":"2024-08-17T16:59:33","modified_gmt":"2024-08-17T20:59:33","slug":"a-review-of-bioartificial-lung-engineering","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-review-of-bioartificial-lung-engineering.php","title":{"rendered":"A Review of Bioartificial Lung Engineering"},"content":{"rendered":"<p>A review paper on one of the trailing areas of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Tissue_engineering\">tissue engineering<\/a> - lungs present a harder and more complex challenge than many other organs: \"End-stage lung disease is a major health care challenge. Lung transplantation remains the definitive treatment, yet <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transplant_rejection\">rejection<\/a> and donor organ shortage limit its broader clinical impact. Engineering bioartificial lung grafts from patient-derived cells could theoretically lead to alternative treatment strategies. Although many challenges on the way to clinical application remain, important early milestones toward translation have been met. Key endodermal <a href=\"http:\/\/en.wikipedia.org\/wiki\/Progenitor_cell\">progenitors<\/a> can be derived from patients and expanded <a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vitro\">in vitro<\/a>. Advanced culture conditions facilitate the <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/05\/a-step-towards-replacement-lungs.php\">formation of three-dimensional functional tissues<\/a> from lineage-committed cells. Bioartificial grafts that provide gas exchange have been <a href=\"http:\/\/www.fightaging.org\/archives\/2010\/06\/more-decellularized-lungs-demonstrated.php\">generated and transplanted into animal models<\/a>. Looking ahead, current challenges in bioartificial lung engineering include creation of ideal scaffold materials, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_differentiation\">differentiation<\/a> and expansion of lung-specific cell populations and full maturation of engineered constructs to provide graft longevity after implantation?<a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vivo\">in vivo<\/a>. A multidisciplinary collaborative effort will not only bring us closer to the ultimate goal of engineering patient-derived lung grafts, but also generate a series of clinically valuable translational milestones such as airway grafts and disease models.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22026560\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22026560<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A review paper on one of the trailing areas of tissue engineering - lungs present a harder and more complex challenge than many other organs: \"End-stage lung disease is a major health care challenge. Lung transplantation remains the definitive treatment, &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-review-of-bioartificial-lung-engineering.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042719","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042719"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042719"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042719\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}