{"id":1042718,"date":"2011-05-01T15:52:10","date_gmt":"2011-05-01T15:52:10","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/a-commentary-on-metformin-studies\/"},"modified":"2024-08-17T16:59:32","modified_gmt":"2024-08-17T20:59:32","slug":"a-commentary-on-metformin-studies","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-commentary-on-metformin-studies.php","title":{"rendered":"A Commentary on Metformin Studies"},"content":{"rendered":"<p>A fairly long open access commentary on <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/09\/metformin-as-calorie-restriction-mimetic.php\">metformin and its effects on slowing aging<\/a> in mice: \"A recent study [may] certainly establish that <a href=\"http:\/\/en.wikipedia.org\/wiki\/Metformin\">metformin<\/a> should be defined as geroprotective or gerosuppressant rather than bona fide [<a href=\"http:\/\/en.wikipedia.org\/wiki\/Caloric_restriction_mimetic\">calorie restriction mimetic<\/a>]. Long-living female mice from the outbred SHR strain were fed metformin in drinking water beginning at 3, 9 or 15 months of age and they were then analyzed for reproductive aging, mean and maximal lifespan and incidence of malignant tumors ... In female SHR mice, [researchers] now confirm that metformin treatment, if started early in life, notably increases by 21% the mean lifespan of tumor-free mice. In contrast, if started late in life, metformin treatment appears to significantly reduce (by 13%) the mean lifespan of tumor-free mice. ... It is perhaps relevant to note that, if started early in life, metformin treatment decreased the risk of death compared to the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Scientific_control\">control group<\/a> whereas similar treatment with metformin at older ages did not affect the relative risk of death in SHR female mice. Metformin's ability to increase the mean lifespan of tumor-free mice while simultaneously decreasing the risk of death in an age-related manner somewhat recapitulate metformin's ability to reduce cancer incidence among <a href=\"http:\/\/en.wikipedia.org\/wiki\/Type_2_diabetes\">type 2 diabetic<\/a> individuals.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.impactaging.com\/papers\/v3\/n4\/full\/100316.html\">http:\/\/www.impactaging.com\/papers\/v3\/n4\/full\/100316.html<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A fairly long open access commentary on metformin and its effects on slowing aging in mice: \"A recent study [may] certainly establish that metformin should be defined as geroprotective or gerosuppressant rather than bona fide [calorie restriction mimetic]. Long-living female &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-commentary-on-metformin-studies.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042718","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042718"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042718"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042718\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}