{"id":1042684,"date":"2011-11-20T16:56:07","date_gmt":"2011-11-20T16:56:07","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/engineering-therapeutic-tissue\/"},"modified":"2024-08-17T16:59:17","modified_gmt":"2024-08-17T20:59:17","slug":"engineering-therapeutic-tissue-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/engineering-therapeutic-tissue-2.php","title":{"rendered":"Engineering Therapeutic Tissue"},"content":{"rendered":"<p>If you can <a href=\"http:\/\/en.wikipedia.org\/wiki\/Tissue_engineering\">build new living tissue<\/a> to be implanted in patients, then why not also give it the capacity to perform additional useful tasks? This is a technology platform with some potential: \"combining gene therapy with tissue engineering could avoid the need for frequent injections of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Recombinant_DNA#Applications_of_recombinant_DNA_technology\">recombinant drugs<\/a>. Patients who rely on recombinant, protein-based drugs must often endure frequent injections, often several times a week, or <a href=\"http:\/\/en.wikipedia.org\/wiki\/Intravenous_therapy\">intravenous therapy<\/a>. Researchers [have demonstrated] the possibility that blood vessels, made from genetically engineered cells, could secrete the drug on demand directly into the bloodstream. ... Such drugs are currently made in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Bioreactor\">bioreactors<\/a> by engineered cells, and are very expensive to make in large amounts. ... The paradigm shift here is, 'why don't we instruct your own cells to be the factory?' ...  [Researchers] provide proof-of-concept, reversing <a href=\"http:\/\/en.wikipedia.org\/wiki\/Anemia\">anemia<\/a> in mice with engineered vessels secreting <a href=\"http:\/\/en.wikipedia.org\/wiki\/Erythropoietin\">erythropoietin (EPO)<\/a>. ... The researchers created the drug-secreting vessels by isolating endothelial colony-forming cells from human blood and inserting a gene instructing the cells to produce EPO. They then added <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mesenchymal_stem_cell\">mesenchymal stem cells<\/a>, suspended the cells in a gel, and injected this mixture into the mice, just under the skin. The cells spontaneously formed networks of blood vessels, lined with the engineered <a href=\"http:\/\/en.wikipedia.org\/wiki\/Endothelium\">endothelial cells<\/a>. Within a week, the vessels hooked up with the animals' own vessels, releasing EPO into the bloodstream. Tests showed that the drug circulated throughout the body and reversed anemia in the mice.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.marketwatch.com\/story\/engineered-drug-secreting-blood-vessels-reverse-anemia-in-mice-2011-11-15\">http:\/\/www.marketwatch.com\/story\/engineered-drug-secreting-blood-vessels-reverse-anemia-in-mice-2011-11-15<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you can build new living tissue to be implanted in patients, then why not also give it the capacity to perform additional useful tasks? This is a technology platform with some potential: \"combining gene therapy with tissue engineering could &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/engineering-therapeutic-tissue-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042684","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042684"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042684"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042684\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}