{"id":1042605,"date":"2010-10-11T17:37:34","date_gmt":"2010-10-11T17:37:34","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/a-summary-of-the-calerie-study\/"},"modified":"2024-08-17T16:58:44","modified_gmt":"2024-08-17T20:58:44","slug":"a-summary-of-the-calerie-study","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-summary-of-the-calerie-study.php","title":{"rendered":"A Summary of the CALERIE Study"},"content":{"rendered":"<p><a href=\"http:\/\/calerie.dcri.duke.edu\" \/>CALERIE<\/a> is the largest present study of <a href=\"http:\/\/www.longevitymeme.org\/topics\/calorie_restriction.cfm\">calorie restriction<\/a> in humans: \"In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/07\/calorie-restriction-produces-the-expected-slowing-of-aging-in-rhesus-monkeys.php\">Nonhuman primate studies<\/a> suggest that CR may have similar effects in longer-lived species. The CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy) research program is the first systematic investigation of CR in nonobese human beings. In the phase 2 study, it is hypothesized that 2 years of sustained CR, involving a 25% reduction of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ad_libitum\">ad libitum<\/a> energy intake, results in beneficial effects similar to those observed in animal studies. ... The study is a multicenter, parallel-group, randomized controlled trial. A sample of 225 participants [is] being enrolled with 2:1 allocation to CR. ... An intensive dietary and behavioral intervention was developed to achieve 25% CR and sustain it over the 2 years. Adherence is monitored using a doubly labeled water technique. Primary outcomes are <a href=\"http:\/\/en.wikipedia.org\/wiki\/Resting_metabolic_rate\">resting metabolic rate<\/a> and core temperature, and are assessed at baseline and at 6-month intervals. Secondary outcomes address <a href=\"http:\/\/en.wikipedia.org\/wiki\/Free-radical_theory\">oxyradical formation<\/a>, cardiovascular risk markers, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Insulin_sensitivity\">insulin sensitivity<\/a> and secretion, immune function, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neuroendocrine_system\">neuroendocrine<\/a> function, quality of life and cognitive function. ... The results will provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects.\"<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20923909\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20923909<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CALERIE is the largest present study of calorie restriction in humans: \"In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/a-summary-of-the-calerie-study.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042605","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042605"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042605"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042605\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}