{"id":1042591,"date":"2011-12-11T16:55:45","date_gmt":"2011-12-11T16:55:45","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/commentary-on-rapamycin\/"},"modified":"2024-08-17T16:58:38","modified_gmt":"2024-08-17T20:58:38","slug":"commentary-on-rapamycin","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/commentary-on-rapamycin.php","title":{"rendered":"Commentary on Rapamycin"},"content":{"rendered":"<p>A commentary on <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/12\/another-rapamycin-lifespan-study.php\">recent research<\/a> into the <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/07\/latelife-administration-of-rapamycin-extends-life-in-mice.php\">effects of rapamycin on longevity<\/a>: \"Aging is a complex process associated with accumulation of damage, loss of function and increased vulnerability to disease, leading ultimately to death. Despite the complicated <a href=\"http:\/\/en.wikipedia.org\/wiki\/Etiology\">etiology<\/a> of aging, an important discovery of recent years has been that simple genetic alterations can cause a substantial increase in healthy lifespan in laboratory model organisms. Many of these longevity-extending mutations down-regulate the activity of the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mammalian_target_of_rapamycin\">mTOR\/S6K pathway<\/a> suggesting that reduced Tor\/S6K signaling promotes entry into alternative phases normally entered during periods of starvation. In fact, <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">dietary restriction (DR)<\/a>, a reduction in food intake without malnutrition, lowers Tor\/S6K signaling and extends the average and maximum life span of a variety of organisms including yeast, flies, worms, fish, and rodents. ... Recently, it has been demonstrated that supplementation with <a href=\"http:\/\/en.wikipedia.org\/wiki\/Rapamycin\">rapamycin<\/a> (an inhibitor of mTOR) started both at 9 and 20 months of life determines a small but significant extension of average and maximal life span in genetically heterogeneous male and female mice ... More studies are needed to understand benefits and side-effects of rapamycin supplementation in different strains of mice and in monkeys as a candidate cancer-preventive and life-extension pharmacological agent. However, the efficacy of intermittent rapamycin treatment in cancer prevention and life span extension [is] very promising since it is likely to reduce the side effects associated with chronic treatment.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/impactaging.com\/papers\/v3\/n11\/full\/100401.html\">http:\/\/impactaging.com\/papers\/v3\/n11\/full\/100401.html<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A commentary on recent research into the effects of rapamycin on longevity: \"Aging is a complex process associated with accumulation of damage, loss of function and increased vulnerability to disease, leading ultimately to death. Despite the complicated etiology of aging, &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/commentary-on-rapamycin.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042591","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042591"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042591"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042591\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}