{"id":1042537,"date":"2011-12-25T16:49:21","date_gmt":"2011-12-25T16:49:21","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/towards-restoring-neural-stem-cell-function-in-the-old\/"},"modified":"2024-08-17T16:58:15","modified_gmt":"2024-08-17T20:58:15","slug":"towards-restoring-neural-stem-cell-function-in-the-old","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/towards-restoring-neural-stem-cell-function-in-the-old.php","title":{"rendered":"Towards Restoring Neural Stem Cell Function in the Old"},"content":{"rendered":"<p>A <a href=\"http:\/\/dx.doi.org\/10.1089\/rej.2011.1301\">Rejuvenation Research<\/a> paper: \"As mammals age, the rate of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neurogenesis\">neurogenesis<\/a> in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesis and the young mice exhibit less neurogenesis, suggesting the importance of systemic circulating factors. <a href=\"http:\/\/en.wikipedia.org\/wiki\/CCL11\">Chemokine CCL11\/eotaxin<\/a> has been identified as a factor that increases with aging. Injections of CCL11 inhibit neurogenesis in young mice, an effect likely mediated by CCR3 <a href=\"http:\/\/en.wikipedia.org\/wiki\/Receptor_(biochemistry)\">receptors<\/a> on neural <a href=\"http:\/\/en.wikipedia.org\/wiki\/Stem_cell\">stem cells<\/a>. Identification of a specific factor that plays a causative role in <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/05\/what-do-failing.php\">stem cell dysfunction in aging<\/a> is consistent with data showing that <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transforming_growth_factor_beta\">transforming growth factor-? (TGF-?)<\/a> inhibits <a href=\"http:\/\/en.wikipedia.org\/wiki\/Satellite_cell\">satellite cell<\/a>-mediated repair. Together, these data suggest that the systemic milieu plays a critical role in the aging of adult stem cells. Because adult stem cells help maintain <a href=\"http:\/\/en.wikipedia.org\/wiki\/Homeostasis\">homeostasis<\/a> by providing the possibility of replacing metabolically damaged <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_differentiation\">differentiated<\/a> cells, aging of the systemic milieu and <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/05\/the-importance-of-the-stem-cell-niche.php\">stem cell niches<\/a> may drive functional decline during aging. The identification of a specific systemic change suggests that aging is more amenable to therapeutic modulation than work on global metabolism-derived damage and cellular senescence implies.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/dx.doi.org\/10.1089\/rej.2011.1301\">http:\/\/dx.doi.org\/10.1089\/rej.2011.1301<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Rejuvenation Research paper: \"As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/towards-restoring-neural-stem-cell-function-in-the-old.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042537","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042537"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042537"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042537\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}