{"id":1042532,"date":"2011-12-25T16:48:53","date_gmt":"2011-12-25T16:48:53","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/calorie-restriction-reduces-mitochondrial-damage\/"},"modified":"2024-08-17T16:58:13","modified_gmt":"2024-08-17T20:58:13","slug":"calorie-restriction-reduces-mitochondrial-damage","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/calorie-restriction-reduces-mitochondrial-damage.php","title":{"rendered":"Calorie Restriction Reduces Mitochondrial Damage"},"content":{"rendered":"<p>A study here shows that <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a> reduces levels of <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">mitochondrial damage that accumulates with age<\/a> - that damage being thought of as a contributing cause of aging - but in different levels in different tissues and different species: \"The hypothesis that life-span extension by caloric restriction (CR) is contingent upon the attenuation of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">macromolecular oxidative damage<\/a> was tested in two different strains of mice: the <a href=\"http:\/\/en.wikipedia.org\/wiki\/C57BL\/6\">C57BL\/6<\/a>, whose life span is extended by CR, and the <a href=\"http:\/\/www.informatics.jax.org\/external\/festing\/mouse\/docs\/DBA.shtml\">DBA\/2<\/a>, in which CR has relatively minor or no impact on longevity. Mice were fed <a href=\"http:\/\/en.wikipedia.org\/wiki\/Ad_libitum\">ad libitum (AL)<\/a> or restricted to 40% lesser food, starting at 4 months of age. Protein damage was measured as protein-linked <a href=\"http:\/\/en.wikipedia.org\/wiki\/Adduct\">adducts<\/a> of <a href=\"http:\/\/en.wikipedia.org\/wiki\/4-hydroxy-2-nonenal\">4-hydroxy-2-nonenal (HNE)<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Malondialdehyde\">malondialdehyde (MDA)<\/a> in skeletal muscle <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondria<\/a> at 6 and 23 months of age. Protein-HNE and -MDA content increased with age in C57BL\/6 mice and CR significantly attenuated these augmentations. ... DBA\/2 mice exhibited little effect of age or CR on protein HNE\/MDA content in skeletal muscle mitochondria. In contrast, protein-HNE levels in liver mitochondria showed a significant increase with age in AL-fed mice of both strains, and CR caused significant attenuation of this damage. Overall, results indicated that the age-related increase in protein oxidative damage and its abatement by CR are genotype- and tissue-specific, and not a universal phenomenon.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22182424\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22182424<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study here shows that calorie restriction reduces levels of mitochondrial damage that accumulates with age - that damage being thought of as a contributing cause of aging - but in different levels in different tissues and different species: \"The &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/calorie-restriction-reduces-mitochondrial-damage.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042532","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042532"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042532"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042532\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}