{"id":1042525,"date":"2012-07-08T15:49:39","date_gmt":"2012-07-08T15:49:39","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/suggesting-a-test-of-rapamycin-and-metformin-together\/"},"modified":"2024-08-17T16:58:10","modified_gmt":"2024-08-17T20:58:10","slug":"suggesting-a-test-of-rapamycin-and-metformin-together","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/suggesting-a-test-of-rapamycin-and-metformin-together.php","title":{"rendered":"Suggesting a Test of Rapamycin and Metformin Together"},"content":{"rendered":"<p><a href=\"http:\/\/www.fightaging.org\/archives\/2012\/05\/rapamycin-slows-aging-in-mice.php\">Rapamycin extends life in mice<\/a> through mechanisms similar to those of <a href=\"http:\/\/www.fightaging.org\/archives\/2001\/11\/calorie-restriction-explained.php\">calorie restriction<\/a>, but has serious side-effects - though researchers are working to <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/03\/separating-out-the-effects-of-rapamycin.php\">separate the positive mechanisms<\/a> from the undesirable negative mechanisms. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Metformin\">Metformin<\/a> is also thought to be a calorie restriction mimetic drug, but <a href=\"http:\/\/www.fightaging.org\/archives\/2012\/05\/metformin-a-review.php\">the evidence for it to extend life in mice is mixed<\/a>. Here, researchers suggest trying both drugs at the same time in the hopes that metformin blunts some of the side-effects of rapamycin: \"Treatment with rapamycin, an inhibitor of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mammalian_target_of_rapamycin#Complexes\">mammalian target of rapamycin complex 1 (mTORC1)<\/a> can increase mammalian life span. However, extended treatment with rapamycin results in increased <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gluconeogenesis\">hepatic gluconeogenesis<\/a> concomitant with glucose and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Insulin_resistance\">insulin insensitivity<\/a> through inhibition of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mammalian_target_of_rapamycin#Complexes\">mTOR complex 2 (C2)<\/a>. Genetic studies show that increased life span associated with mTORC1 inhibition can be at least partially decoupled from increased gluconeogenesis associated with mTORC2 inhibition. <a href=\"http:\/\/en.wikipedia.org\/wiki\/AMP-activated_protein_kinase\">Adenosine monophosphate kinase (AMPK)<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/Agonist\">agonists<\/a> such as metformin, which inhibits gluconeogenesis, [might] be expected to block the glucose dysmetabolism mediated by rapamycin.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/dx.doi.org\/10.1089\/rej.2012.1347\">http:\/\/dx.doi.org\/10.1089\/rej.2012.1347<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapamycin extends life in mice through mechanisms similar to those of calorie restriction, but has serious side-effects - though researchers are working to separate the positive mechanisms from the undesirable negative mechanisms. Metformin is also thought to be a calorie &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/suggesting-a-test-of-rapamycin-and-metformin-together.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042525","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042525"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042525"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042525\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}