{"id":1042511,"date":"2012-01-01T16:48:13","date_gmt":"2012-01-01T16:48:13","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/oxidative-stress-and-gender-longevity-differences\/"},"modified":"2024-08-17T16:58:05","modified_gmt":"2024-08-17T20:58:05","slug":"oxidative-stress-and-gender-longevity-differences","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/oxidative-stress-and-gender-longevity-differences.php","title":{"rendered":"Oxidative Stress and Gender Longevity Differences"},"content":{"rendered":"<p>Here is another of the many theories aiming to explain why <a href=\"http:\/\/www.fightaging.org\/archives\/2011\/01\/revisiting-the-gender-longevity-gap-once-more.php\">women live longer than men<\/a>: \"One of the most significant achievements of the twentieth century is the increase in human lifespan. In any period studied, females live longer than males. We showed that <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">mitochondrial oxidative stress<\/a> is higher in males than females and that the higher levels of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Estrogen\">estrogens<\/a> in females protect them against ageing, by up-regulating the expression of antioxidant, longevity-related genes. The chemical structure of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Estradiol\">estradiol<\/a> confers antioxidant properties to the molecule. However, the low concentration of estrogens in females makes it unlikely that they exhibit significant antioxidant capacity in the organism. Therefore we studied the mechanisms enabling estradiol to be antioxidant at physiological levels. Our results show that physiological concentrations of estrogens activate estrogen <a href=\"http:\/\/en.wikipedia.org\/wiki\/Receptor_(biochemistry)\">receptors<\/a> and the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitogen-activated_protein_kinase\">MAPK<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/NF-%CE%BAB\">NFKB<\/a> pathway. Activation of NFkB by estrogens subsequently activates the expression of <a href=\"http:\/\/en.wikipedia.org\/wiki\/SOD2\">Mn-SOD<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/GPX2_(gene)\">GPx<\/a>. Moreover, we have demonstrated that <a href=\"http:\/\/en.wikipedia.org\/wiki\/Genistein\">genistein<\/a>, the most abundant <a href=\"http:\/\/en.wikipedia.org\/wiki\/Phytoestrogens\">phytoestrogen<\/a> in soya, reproduces the antioxidant effect of estradiol at nutritionally relevant concentrations by the same mechanism ... We conclude that estrogens and phytoestrogens up-regulate expression of antioxidant enzymes via the estrogen receptor and MAPK activation, which in turn activate the NFkB <a href=\"http:\/\/en.wikipedia.org\/wiki\/Signalling_pathway\">signalling pathway<\/a>, resulting in the up-regulation of the expression of longevity-related genes.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22188448\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22188448<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here is another of the many theories aiming to explain why women live longer than men: \"One of the most significant achievements of the twentieth century is the increase in human lifespan. In any period studied, females live longer than &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/oxidative-stress-and-gender-longevity-differences.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042511","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042511"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042511"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042511\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}