{"id":1042506,"date":"2012-07-08T15:49:46","date_gmt":"2012-07-08T15:49:46","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/nitric-oxide-and-aging-blood-vessels\/"},"modified":"2024-08-17T16:58:03","modified_gmt":"2024-08-17T20:58:03","slug":"nitric-oxide-and-aging-blood-vessels","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/nitric-oxide-and-aging-blood-vessels.php","title":{"rendered":"Nitric Oxide and Aging Blood Vessels"},"content":{"rendered":"<p><a href=\"http:\/\/www.fightaging.org\/archives\/2007\/03\/nitric-oxide-everywhere.php\">Nitric oxide levels<\/a> are a possible target for therapies aimed at some of the <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/09\/nitric-oxide-and-aging-blood-vessels.php\">signs of aging in blood vessels<\/a>: \"Many disorders emerge with advancing aging, and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cardiovascular_disease\">cardiovascular diseases (CVD)<\/a> are a major cause of morbidity and mortality in the elderly. The term vascular aging encompasses all the structural and functional alterations in the blood vessels with progressive aging. Both <a href=\"http:\/\/en.wikipedia.org\/wiki\/Smooth_muscle_tissue\">smooth muscle cells<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Tunica_intima\">intima layers<\/a> are affected. These vascular changes lead to endothelial dysfunction, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Arterial_stiffness\">arterial stiffness<\/a> in consequence of intense remodeling and calcification, impaired <a href=\"http:\/\/en.wikipedia.org\/wiki\/Angiogenesis\">angiogenesis<\/a>, greater susceptibility to vascular injury and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Atherosclerosis\">atherosclerotic lesions<\/a>. The mechanisms underlying vascular aging are complex and involve multiple pathways and factors ... In this complex scenario, vascular function depends on the balanced production\/bioavailability of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nitric_oxide\">nitric oxide (NO)<\/a>, which is maintained by the normal activity of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Endothelial_nitric_oxide_synthase\">endothelial nitric oxide synthase (eNOS)<\/a>. On the other hand, excessive amount of NO produced by <a href=\"http:\/\/en.wikipedia.org\/wiki\/Inducible_nitric_oxide_synthase#iNOS\">inducible nitric oxide synthase (iNOS)<\/a> up-regulation contributes to vascular dysfunction. Evidence obtained from <a href=\"http:\/\/en.wikipedia.org\/wiki\/Animal_model\">experimental models<\/a> indicates that decreased NO bioavailability as well as increased <a href=\"http:\/\/en.wikipedia.org\/wiki\/Reactive_nitrogen_species\">reactive nitrogen species (RNS)<\/a> production contributes to aging-associated vascular dysfunction. ... Pharmacological modulation of NO generation and expression\/activity of NOS isoforms may represent a therapeutic alternative to prevent the progression of cardiovascular diseases.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3382417\/\">http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3382417\/<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nitric oxide levels are a possible target for therapies aimed at some of the signs of aging in blood vessels: \"Many disorders emerge with advancing aging, and cardiovascular diseases (CVD) are a major cause of morbidity and mortality in the &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/nitric-oxide-and-aging-blood-vessels.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042506","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042506"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042506"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042506\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}