{"id":1042489,"date":"2012-01-15T16:50:43","date_gmt":"2012-01-15T16:50:43","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/another-update-on-a-tissue-engineered-trachea-transplant\/"},"modified":"2024-08-17T16:57:52","modified_gmt":"2024-08-17T20:57:52","slug":"another-update-on-a-tissue-engineered-trachea-transplant","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/another-update-on-a-tissue-engineered-trachea-transplant.php","title":{"rendered":"Another Update on a Tissue Engineered Trachea Transplant"},"content":{"rendered":"

One of the world's more active tissue engineering<\/a> research and development groups works on building replacement tracheas<\/a> from a scaffold and the patient's own cells. They have carried a number of successful transplants in recent years, and seem on a par with Tengion's work on bladders<\/a>, or the folk producing heart valves for children<\/a> in terms of outcomes and technological sophistication.<\/p>\n

Here's an update on a transplant carried out late last year<\/a>:<\/p>\n

Surgeons in Sweden have replaced the cancerous windpipe of a Maryland man with one made in a laboratory and seeded with the man's cells.<\/p>\n

...<\/p>\n

\"What we did is surgically remove his malignant tumor,\" Dr. Macchiarini said. \"Then we replaced the trachea with this tissue-engineered scaffold.\" The Y-shaped scaffold, fashioned from nano-size fibers of a type of plastic called PET that is commonly used in soda bottles, was seeded with stem cells from Mr. Lyles's bone marrow. It was then placed in a bioreactor<\/a> - a shoebox-size container holding the stem cells in solution - and rotated like a rotisserie chicken to allow the cells to soak in.<\/p>\n

After two of days, it was installed in Mr. Lyles during an elaborate operation in which it was sutured to his throat and lungs. All told, the treatment cost about $450,000, Mr. Lyles said.<\/p>\n

...<\/p>\n

Dr. Macchiarini has performed a dozen trachea transplants since 2008, but the first 10 used organs from cadavers in which all the living cells were removed, leaving behind a natural scaffold of cartilage<\/a>. Donated tracheas are rare, however, and are never a perfect fit. In Mr. Lyle's case, and in the case of an Eritrean man who received a similar transplant last June and is doing well, the synthetic scaffold is made using CT scans<\/a> of the existing trachea to ensure it matches precisely.<\/i><\/p><\/blockquote>\n

The cost of the first tissue engineered parts will fall dramatically once the procedures become more widespread and the underlying technologies more robust and commoditized<\/a>. But costs will not fall as far is they would in an actual free market in medicine<\/a>, and there will be long and unnecessary years of delay - and vast expense for the sponsoring companies - before regulators in wealthy Western countries will approve these new applications of cell science for broad use.<\/p>\n

Source:
http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

One of the world's more active tissue engineering research and development groups works on building replacement tracheas from a scaffold and the patient's own cells. They have carried a number of successful transplants in recent years, and seem on a … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042489","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042489"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042489"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042489\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}