{"id":1042469,"date":"2012-01-15T16:50:57","date_gmt":"2012-01-15T16:50:57","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/looking-for-evidence-of-inherited-longevity-in-cells\/"},"modified":"2024-08-17T16:57:44","modified_gmt":"2024-08-17T20:57:44","slug":"looking-for-evidence-of-inherited-longevity-in-cells","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/looking-for-evidence-of-inherited-longevity-in-cells.php","title":{"rendered":"Looking for Evidence of Inherited Longevity in Cells"},"content":{"rendered":"<p>Researchers are examining cellular biochemistry in people who belong to long-lived families: \"The offspring of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nonagenarian\">nonagenarian<\/a> siblings suffer less from age related conditions and have a lower risk of mortality compared to their partners. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Fibroblast\">Fibroblast<\/a> strains derived from such offspring in middle age show different <a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vitro\">in vitro<\/a> responses to stress, more stress-induced <a href=\"http:\/\/en.wikipedia.org\/wiki\/Apoptosis\">apoptosis<\/a> and less <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_senescence\">senescence<\/a> when compared to strains of their partners. Aiming to find differences in cellular metabolism in vitro between these fibroblast strains, [cells were] analysed using (1)H <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nuclear_magnetic_resonance\">nuclear magnetic resonance (NMR)<\/a>-based metabolic footprinting. ... Strains from offspring and their partners were compared ... The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Glutamine\">ala-gln<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Glucose\">glucose<\/a> consumption were higher for fibroblast strains derived from offspring when compared to strains of their partners. Also, production of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Glutamine\">glutamine<\/a>, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alanine\">alanine<\/a>, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lactate\">lactate<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Pyroglutamic_ac\">pyroglutamic acid<\/a> was found to be higher for fibroblast strains derived from offspring. In conclusion, differences in NMR-based metabolic profiles of human cells in vitro reflect the propensity for human longevity of the subjects from whom these were derived.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22218423\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22218423<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers are examining cellular biochemistry in people who belong to long-lived families: \"The offspring of nonagenarian siblings suffer less from age related conditions and have a lower risk of mortality compared to their partners. Fibroblast strains derived from such offspring &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/looking-for-evidence-of-inherited-longevity-in-cells.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042469","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042469"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042469"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042469\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}