{"id":1042406,"date":"2010-05-22T08:17:46","date_gmt":"2010-05-22T08:17:46","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/affibodies-and-aggregates\/"},"modified":"2024-08-17T16:57:17","modified_gmt":"2024-08-17T20:57:17","slug":"affibodies-and-aggregates","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/affibodies-and-aggregates.php","title":{"rendered":"Affibodies and Aggregates"},"content":{"rendered":"<p>From the <a href=\"http:\/\/www.sens.org\/node\/785\">SENS Foundation<\/a>: \"Aggregates of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Beta_amylo\">beta-amyloid (Abeta)<\/a> and other malformed proteins accumulate in brain aging and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neurodegenerative_disease\">neurodegenerative disease<\/a>, leading progressively to <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neuron\">neuronal<\/a> dysfunction and\/or loss. The <a href=\"http:\/\/www.sens.org\/sens-research\/research-themes\">regenerative engineering solution<\/a> to these insults is <a href=\"http:\/\/www.sens.org\/sens-research\/research-themes\/amylosens\">therapeutic clearance of aggregates<\/a>, extracellular (such as Abeta plaques) and <a href=\"http:\/\/www.sens.org\/sens-research\/research-themes\/lysosens\">intracellular<\/a> (such as soluble, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oligomer\">oligomeric<\/a> Abeta). Immunotherapeutic Abeta clearance from the brain is a very active field of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alzheimer's_disease\">Alzheimer's research<\/a>, with at least seven passive, and several second-generation active, <a href=\"http:\/\/www.longevitymeme.org\/news\/view_news_item.cfm?news_\">Abeta vaccines<\/a> currently in human <a href=\"http:\/\/en.wikipedia.org\/wiki\/Clinical_trial\">clinical trials<\/a> ... One challenge to optimal vaccine design is matching the specificity of antibodies the range of Abeta aggregates that form <a href=\"http:\/\/en.wikipedia.org\/wiki\/In_vivo\">in vivo<\/a> ... agents that sequester one Abeta species may leave other species intact, and in some cases a shift in assembly dynamics can actually promote the formation of one species while clearing or reducing the formation of others ... Although in very early in vivo testing, a new approach has emerged that may offer that promise. This is the use of an <a href=\"http:\/\/en.wikipedia.org\/wiki\/Affibody_molecule\">Abeta-targeting affibody<\/a>, i.e., a novel non-<a href=\"http:\/\/en.wikipedia.org\/wiki\/Immunoglobulin\">immunoglobulin<\/a> binding protein generated through combinatorial protein engineering.\"<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.sens.org\/node\/785\">http:\/\/www.sens.org\/node\/785<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the SENS Foundation: \"Aggregates of beta-amyloid (Abeta) and other malformed proteins accumulate in brain aging and neurodegenerative disease, leading progressively to neuronal dysfunction and\/or loss. The regenerative engineering solution to these insults is therapeutic clearance of aggregates, extracellular (such &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/affibodies-and-aggregates.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042406","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042406"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042406"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042406\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}