{"id":1042389,"date":"2010-04-09T08:43:02","date_gmt":"2010-04-09T08:43:02","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/the-contributions-of-mitochondria-to-longevity\/"},"modified":"2024-08-17T16:57:09","modified_gmt":"2024-08-17T20:57:09","slug":"the-contributions-of-mitochondria-to-longevity-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/the-contributions-of-mitochondria-to-longevity-2.php","title":{"rendered":"The Contributions of Mitochondria to Longevity"},"content":{"rendered":"<p>Manipulating the machinery of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\">mitochondria<\/a> - the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Electron_transport_chain\">respiratory chain<\/a> that turns food into <a href=\"http:\/\/en.wikipedia.org\/wiki\/Adenosine_triphosphate\">the chemical ATP<\/a> that is used to power cellular biochemistry - can extend healthy life in a variety of species. Here, researchers dig deeper into the mechanisms by which this happens, finding that there are more than one: \"In <a href=\"http:\/\/en.wikipedia.org\/wiki\/Caenorhabditis_elegans\">Caenorhabditis elegans<\/a> longevity is increased by a partial loss-of-function mutation in the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Electron_transport_chain#Complex_III\">mitochondrial complex III<\/a> subunit gene isp-1. Longevity is also increased by <a href=\"http:\/\/en.wikipedia.org\/wiki\/RNA_interference\">RNAi<\/a> against the expression of a variety of mitochondrial respiratory chain genes, including isp-1, but it is unknown whether the isp-1(qm150) mutation and the RNAi treatments trigger the same underlying mechanisms of longevity. We have identified nuo-6(qm200), a mutation [that] reduces the function of complex I and, like isp-1(qm150), results in low oxygen consumption, slow growth, slow behavior, and increased lifespan. We [compared] nuo-6(qm200) [to] nuo-6(RNAi) and found them to be distinct in crucial ways, including patterns of growth and fertility, behavioral rates, oxygen consumption, ATP levels, <a href=\"http:\/\/www.fightaging.org\/archives\/2007\/05\/autophagy.php\">autophagy<\/a>, [as] well as <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expression<\/a> of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Superoxide_dismutase\">superoxide dismutases<\/a>, mitochondrial <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/10\/manipulation-of-heat-shock-proteins-as-the-next-big-thing.php\">heat shock proteins<\/a>, and other gene expression markers. RNAi treatments appear to generate a stress and autophagy response, while the genomic mutation alters <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/10\/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php\">electron transport and reactive oxygen species metabolism<\/a>. ... Most importantly, we found that [the] lifespan increase induced by nuo-6(RNAi) is fully additive to that induced by isp-1(qm150), and the increase induced by isp-1(RNAi) is fully additive to that induced by nuo-6(qm200). Our results demonstrate that distinct and separable aspects of mitochondrial biology affect lifespan independently.\"<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/pmid.us\/20346072\">http:\/\/pmid.us\/20346072<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Manipulating the machinery of mitochondria - the respiratory chain that turns food into the chemical ATP that is used to power cellular biochemistry - can extend healthy life in a variety of species. Here, researchers dig deeper into the mechanisms &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/the-contributions-of-mitochondria-to-longevity-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042389","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042389"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042389"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042389\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}