{"id":1042376,"date":"2012-02-05T16:49:10","date_gmt":"2012-02-05T16:49:10","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/age-changes-the-extracellular-matrix\/"},"modified":"2024-08-17T16:57:03","modified_gmt":"2024-08-17T20:57:03","slug":"age-changes-the-extracellular-matrix","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/age-changes-the-extracellular-matrix.php","title":{"rendered":"Age Changes the Extracellular Matrix"},"content":{"rendered":"<p>The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Extracellular_matrix\">extracellular matrix (ECM)<\/a> surrounds and supports cells, both structurally and in a range of other ways, such as by mediating cell signalling. With age, however, the ECM changes for a variety of reasons - <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/06\/why-do-we-accumulate-senescent-cells-anyway.php\">it is damaged by the actions of senescent cells<\/a>, for example. This has consequences, such as on the capacity of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Stem_cell\">stem cells<\/a> to maintain tissue. Here is a review paper: \"Aging is characterized by reduced tissue and organ function, regenerative capacity, and accompanied by a <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/06\/friday-science-aging-stem-cells-and-stem-cell-niches.php\">decrease in tissue resident stem cell numbers and a loss of potency<\/a>. The impact of aging on stem cell populations differs between tissues and depends on a number of non cell-intrinsic factors, including systemic changes associated with <a href=\"http:\/\/www.fightaging.org\/archives\/2006\/12\/when-and-how-does-the-decay-of-your-immune-system.php\">immune system alterations<\/a>, as well as senescence related changes of the local <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cytoarchitecture\">cytoarchitecture<\/a>. The latter has been studied in the context of <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/05\/the-importance-of-the-stem-cell-niche.php\">environmental niche properties required for stem cell maintenance<\/a>. Here, we will discuss the impact of the extracellular matrix (ECM) on stem cell maintenance, its changes during aging and its significance for stem cell therapy. ... It is concluded that a remodeled ECM due to <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/02\/inflammation-and-the-damage-of-aging.php\">age related inflammation<\/a>, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Fibrosis\">fibrosis<\/a> or <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">oxidative stress<\/a> provides an inadequate environment for endogenous regeneration or stem cell therapies.\" The question of whether an old body can fully benefit from stem cell therapies continues to arise - eventually the stem cell research community will <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/02\/inserting-repair-of-aging-into-tissue-engineering.php\">have to start addressing the damage of aging<\/a> in order to assure the performance of their therapies when treating the old.<\/p>\n<p><span>Link: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22285947\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22285947<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The extracellular matrix (ECM) surrounds and supports cells, both structurally and in a range of other ways, such as by mediating cell signalling. With age, however, the ECM changes for a variety of reasons - it is damaged by the &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/age-changes-the-extracellular-matrix.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042376","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042376"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042376"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042376\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}