{"id":1042365,"date":"2013-04-14T02:59:54","date_gmt":"2013-04-14T06:59:54","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/longevity-medicine\/examining-the-biochemistry-of-arctica-islandica-longevity.php"},"modified":"2024-08-17T16:56:57","modified_gmt":"2024-08-17T20:56:57","slug":"examining-the-biochemistry-of-arctica-islandica-longevity","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/examining-the-biochemistry-of-arctica-islandica-longevity.php","title":{"rendered":"Examining the Biochemistry of Arctica Islandica Longevity"},"content":{"rendered":"

The clam species Arctica islandica is very long-lived<\/a>, reaching at least four centuries in the wild. Researchers are comparing its biochemistry with similar but shorter-lived species<\/a> to see if they can pinpoint the mechanisms that lead to its exceptional longevity. Here is recent research on this topic:<\/p>\n

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The observation of an inverse relationship between lifespan and mitochondrial H2 O2 production rate<\/a> would represent strong evidence for the disputed oxidative stress theory of aging<\/a>. Studies on this subject using invertebrates<\/a> are surprisingly lacking, despite their significance in both taxonomic richness and biomass. Bivalve molluscs<\/a> represent an interesting taxonomic group to challenge this relationship. They are exposed to environmental constraints such as microbial H2 S<\/a>, anoxia<\/a>\/reoxygenation, and temperature variations known to elicit oxidative stress<\/a>. Their mitochondrial electron transport system<\/a> is also connected to an alternative oxidase<\/a> that might improve their ability to modulate [the reactive oxygen species (ROS)<\/a> generated by mitochondria and which produce oxidative stress].<\/p>\n

Here we compared H2 O2<\/a> production rates in isolated mantle mitochondria<\/a> between the longest living metazoan<\/a> & the bivalve Arctica islandica & and two taxonomically related species of comparable size. In an attempt to test mechanisms previously proposed to account for a reduction of ROS production in long-lived species, we compared oxygen consumption of isolated mitochondria and enzymatic activity of different complexes<\/a> of the electron transport system in the two species with the greatest difference in longevity. <\/p>\n

We found that A. islandica mitochondria produced significantly less [of the reactive oxygen species] H2 O2 than those of the two short-lived species in nearly all conditions of mitochondrial respiration<\/a> tested, including forward, reverse, and convergent electron flow. Alternative oxidase activity does not seem to explain these differences. However, our data suggest that reduced complex I and III activity can contribute to the lower ROS production of A. islandica mitochondria, in accordance with previous studies.<\/i><\/p>\n<\/blockquote>\n

Reduced activity within mitochondria in this sense shows up in some longevity-inducing mutations in laboratory animals. Mitochondrial activity and composition (how much damage they cause per unit time, and how resistant they are to damage) appears to be very important as a determinant of longevity differences between species<\/a>. This should increase our interest in ways to repair mitochondrial damage<\/a> in humans as a potential rejuvenation therapy<\/a>.<\/p>\n

Link: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23566066<\/a><\/span><\/p>\n

Source:
http:\/\/www.fightaging.org\/archives\/2013\/04\/examining-the-biochemistry-of-arctica-islandica-longevity.php<\/a><\/p>\n

Source:
http:\/\/www.longevitymedicine.tv\/examining-the-biochemistry-of-arctica-islandica-longevity\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The clam species Arctica islandica is very long-lived, reaching at least four centuries in the wild. Researchers are comparing its biochemistry with similar but shorter-lived species to see if they can pinpoint the mechanisms that lead to its exceptional longevity. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042365","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042365"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042365"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042365\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}