{"id":1042273,"date":"2012-11-25T07:49:38","date_gmt":"2012-11-25T07:49:38","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/longevity-medicine\/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing.php"},"modified":"2024-08-17T16:56:04","modified_gmt":"2024-08-17T20:56:04","slug":"t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing.php","title":{"rendered":"T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing"},"content":{"rendered":"<p>We describe here a novel vector (CD8-LV) derived from lentivirus, which delivers genes exclusively and specifically to CD8+ cells. CD8-LV mediated stable in vitro and in vivo reporter gene transfer as well as efficient transfer of genes encoding TCRs recognizing the melanoma antigen tyrosinase. Strikingly, T cells genetically modified with CD8-LV killed melanoma cells reproducibly more efficiently than CD8+ cells transduced with a conventional lentiviral vector. Neither TCR expression levels, nor the rate of activation-induced death of transduced cells differed between both vector types. Instead, CD8-LV transduced cells showed increased granzyme B and perforin levels as well as an up-regulation of CD8 surface expression in a small subpopulation of cells. Thus, a possible mechanism for CD8-&#8230;Source:<br \/><a href=\"http:\/\/www.medworm.com\/index.php?rid=6763105&amp;cid=c_449_19_f&amp;fid=29474&amp;url=http%3A%2F%2Fbloodjournal.hematologylibrary.org%2Fcgi%2Fcontent%2Fshort%2F120%2F22%2F4334%3Frss%3D1\">http:\/\/www.medworm.com\/index.php?rid=6763105&#038;cid=c_449_19_f&#038;fid=29474&#038;url=http%3A%2F%2Fbloodjournal.hematologylibrary.org%2Fcgi%2Fcontent%2Fshort%2F120%2F22%2F4334%3Frss%3D1<\/a><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymedicine.tv\/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing\/\">http:\/\/www.longevitymedicine.tv\/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We describe here a novel vector (CD8-LV) derived from lentivirus, which delivers genes exclusively and specifically to CD8+ cells. CD8-LV mediated stable in vitro and in vivo reporter gene transfer as well as efficient transfer of genes encoding TCRs recognizing &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042273","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042273"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042273"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042273\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}