{"id":1042222,"date":"2012-10-28T07:44:17","date_gmt":"2012-10-28T07:44:17","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/longevity-medicine\/more-on-young-blood-and-old-mice.php"},"modified":"2024-08-17T16:55:37","modified_gmt":"2024-08-17T20:55:37","slug":"more-on-young-blood-and-old-mice","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/more-on-young-blood-and-old-mice.php","title":{"rendered":"More on Young Blood and Old Mice"},"content":{"rendered":"

Some of the effects of aging are driven by signaling changes in important parts of our biochemistry – such as in stem cell niches<\/a>, collections of cells that provide necessary support to the stem cells<\/a> that maintain and repair tissue. Niches increasingly act to suppress the stem cells they contain<\/a> in response to rising levels of cellular and other damage connected to aging<\/a>. The stem cells themselves also suffer damage, and this evolved response is likely a way to minimize the risk of cancer at the cost of maintaining tissues, but the declining function of the stem cells so far seems to be far more a property of signals from the niche.<\/p>\n

In the course of investigating this and similar effects, researchers have been moving blood between young and old mice<\/a>. Transfusions and joining the bloodstreams of young and old mice are a way to change the signaling environment in order to see what the effects are. The outcome is that a range of measures of aging are reversed:<\/p>\n

\n

Experiments on mice have shown that it is possible to rejuvenate the brains of old animals by injecting them with blood from the young. … blood from young mice reversed some of the effects of ageing in the older mice, improving learning and memory to a level comparable with much younger animals.<\/p>\n

[Researchers] connected the circulatory systems of an old and young mouse so that their blood could mingle. This is a well-established technique used by scientists to study the immune system<\/a> called heterochronic parabiosis<\/a>. When [researchers] examined the old mouse after several days, [they] found several clear signs that the ageing process had slowed down. The number of stem cells in the brain, for example, had increased. More important, [they] found a 20% increase in connections between brain cells. <\/p>\n

One of the main things that changes with ageing are these connections, there are a lot less of them as we get older. That is thought to underlie memory impairment – if you have less connections, neurons aren’t communicating, all of a sudden you have [problems] in learning and memory. … the young blood most likely reversed ageing by topping up levels of key chemical factors that tend to decline in the blood as animals age. Reintroduce these and [all] of a sudden you have all of these plasticity<\/a> and learning and memory-related genes that are coming back.<\/i><\/p>\n<\/blockquote>\n

Link: http:\/\/www.guardian.co.uk\/science\/2012\/oct\/17\/young-blood-reverse-effects-ageing<\/a><\/span><\/p>\n

Source:
http:\/\/www.fightaging.org\/archives\/2012\/10\/more-on-young-blood-and-old-mice.php<\/a><\/p>\n

Source:
http:\/\/www.longevitymedicine.tv\/more-on-young-blood-and-old-mice\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Some of the effects of aging are driven by signaling changes in important parts of our biochemistry – such as in stem cell niches, collections of cells that provide necessary support to the stem cells that maintain and repair tissue. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042222","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042222"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042222"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042222\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}