{"id":1042060,"date":"2012-05-20T15:45:46","date_gmt":"2012-05-20T15:45:46","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/longevity-medicine\/on-engineering-functional-cartilage.php"},"modified":"2024-08-17T16:54:07","modified_gmt":"2024-08-17T20:54:07","slug":"on-engineering-functional-cartilage","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/on-engineering-functional-cartilage.php","title":{"rendered":"On Engineering Functional Cartilage"},"content":{"rendered":"<p>An article from the <a href=\"http:\/\/www.wellcome.ac.uk\/News\/2012\/Features\/WTVM054966.htm\">Wellcome Trust<\/a>: &#8220;Researchers have been engineering <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cartilage\">cartilage<\/a> in the laboratory for 15 years or more, but as yet the tissues they have created don&#8217;t function properly in human joints. [Researchers] are taking a new approach to try to bridge the gap between laboratory-created cartilage and the tissue our bodies make. &#8230; Biological texts show that these lab-grown tissues have the appearance, texture, and protein and mineral components of bone and cartilage. But once they are tested in an animal, these tissues simply don&#8217;t behave quite like the natural tissues they are supposed to replicate. &#8230; Joints are remarkable feats of engineering, but efforts to grow them in the lab have focused mostly on their biology. &#8230; Biologists attempting to create cartilage and bone over the past 15 years have typically tested the mechanical properties of their laboratory-grown tissue &#8211; for example, whether it is rubbery and resilient enough when pressure is applied. &#8230; Just because biological tests indicate a tissue looks like bone and feels like bone, doesn&#8217;t actually mean it is bone &#8230; This is where an engineering perspective becomes important. To look at how close a match these laboratory-generated tissues really are to native bone and cartilage, [researchers] supplemented the biological analyses with engineering tests, such as <a href=\"http:\/\/en.wikipedia.org\/wiki\/Raman_spectroscopy\">bio-Raman microspectroscopy<\/a>. &#8230; You shine a laser on the material, and the way the light scatters gives you an idea of the bonds between its components. Different mineral types form different bonds, so you get a much more precise picture of what is actually present. &#8230; If a lab-grown tissue seems from some tests to be the real thing but isn&#8217;t really, then it won&#8217;t behave like it once it has been implanted in a human body. &#8230; [The researchers aim] to use an engineering approach to create a whole osteochondral interface in which bone and cartilage transition seamlessly into each other like they do in the body. &#8230; That&#8217;s the only way it will effectively transmit loads to the underlying bone. And because bone will heal, it will heal the construct into the joint.&#8221;<\/p>\n<p><span>Link: <a href=\"http:\/\/www.wellcome.ac.uk\/News\/2012\/Features\/WTVM054966.htm\">http:\/\/www.wellcome.ac.uk\/News\/2012\/Features\/WTVM054966.htm<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymedicine.tv\/feed\/\">http:\/\/www.longevitymedicine.tv\/feed\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An article from the Wellcome Trust: &#8220;Researchers have been engineering cartilage in the laboratory for 15 years or more, but as yet the tissues they have created don&#8217;t function properly in human joints. [Researchers] are taking a new approach to &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/on-engineering-functional-cartilage.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1042060","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042060"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1042060"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1042060\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1042060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1042060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1042060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}