{"id":1041813,"date":"2011-03-22T17:12:38","date_gmt":"2011-03-22T17:12:38","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/gene-therapy-trials-to-treat-parkinson%e2%80%99s-disease\/"},"modified":"2024-08-17T16:51:52","modified_gmt":"2024-08-17T20:51:52","slug":"gene-therapy-trials-to-treat-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/gene-therapy-trials-to-treat-parkinsons-disease.php","title":{"rendered":"Gene Therapy Trials to Treat Parkinson\u2019s Disease"},"content":{"rendered":"<p>Via <a href=\"http:\/\/www.eurekalert.org\/pub_releases\/2011-03\/nyph-gtr031411.php\">EurekAlert!<\/a>: &#8220;A <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gene_therapy\">gene therapy<\/a> called NLX-P101 dramatically reduces movement impairment in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Parkinson's_disease\">Parkinson&#8217;s patients<\/a>, according to results of a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Clinical_trial#Phase_II\">Phase 2<\/a> study &#8230; The approach introduces a gene into the brain to normalize chemical signaling. &#8230; The study is the first successful randomized, double-blind clinical trial of a gene therapy for Parkinson&#8217;s or any neurologic disorder &#8230; Half of patients receiving gene therapy achieved dramatic symptom improvements, compared with just 14 percent in the control group. Overall, patients receiving gene therapy had a 23.1 percent improvement in motor score, compared to a 12.7 percent improvement in the control group. &#8230; Improved motor control was seen at one month and continued virtually unchanged throughout the six-month study period. &#8230; Gene therapy is the use of a gene to change the function of cells or organs to improve or prevent disease. To transfer genes into cells, an inert virus is used to deliver the gene into a target cell. In this case, the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Glutamic_acid_decarboxylase\">glutamic acid decarboxylase (GAD)<\/a> gene was used because GAD makes a chemical called <a href=\"http:\/\/en.wikipedia.org\/wiki\/GABA\">GABA<\/a>, a major inhibitory <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neurotransmitter\">neurotransmitter<\/a> in the brain that helps &#8216;quiet&#8217; excessive neuronal firing related to Parkinson&#8217;s disease. &#8230; In Parkinson&#8217;s disease, not only do patients lose many <a href=\"http:\/\/en.wikipedia.org\/wiki\/Dopamine\">dopamine<\/a>-producing brain cells, but they also develop substantial reductions in the activity and amount of GABA in their brains. This causes a dysfunction in brain circuitry responsible for coordinating movement.&#8221;<\/p>\n<p><span>Link: <a href=\"http:\/\/www.eurekalert.org\/pub_releases\/2011-03\/nyph-gtr031411.php\">http:\/\/www.eurekalert.org\/pub_releases\/2011-03\/nyph-gtr031411.php<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Via EurekAlert!: &#8220;A gene therapy called NLX-P101 dramatically reduces movement impairment in Parkinson&#8217;s patients, according to results of a Phase 2 study &#8230; The approach introduces a gene into the brain to normalize chemical signaling. &#8230; The study is the &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/gene-therapy-trials-to-treat-parkinsons-disease.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1041813","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041813"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1041813"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041813\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1041813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1041813"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1041813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}