{"id":1041784,"date":"2011-02-22T18:13:55","date_gmt":"2011-02-22T18:13:55","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/stem-cells-versus-kidney-damage\/"},"modified":"2024-08-17T16:51:41","modified_gmt":"2024-08-17T20:51:41","slug":"stem-cells-versus-kidney-damage","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/stem-cells-versus-kidney-damage.php","title":{"rendered":"Stem Cells Versus Kidney Damage"},"content":{"rendered":"<p>A promising <a href=\"http:\/\/www.ingentaconnect.com\/content\/cog\/cm\/2010\/00000001\/00000003\/art00002\">open access study<\/a>: &#8220;Transplanting <a href=\"http:\/\/en.wikipedia.org\/wiki\/Autotransplantation\">autologous<\/a> renal <a href=\"http:\/\/en.wikipedia.org\/wiki\/Progenitor_cell\">progenitor cells<\/a> (RPCs), (kidney stem cells derived from self-donors), into <a href=\"http:\/\/en.wikipedia.org\/wiki\/Animal_model\">rat models<\/a> with kidney damage from <a href=\"http:\/\/en.wikipedia.org\/wiki\/Pyelonephritis\">pyelonephritis<\/a> &#8211; a type of urinary infection that has reached the kidney &#8211; has been found to improve kidney structure and function. &#8230; Advancements in stem cell therapies and tissue engineering hold great promise for regenerative <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nephrology\">nephrology<\/a>. Our RPC transplant study demonstrated benefits for pyelonephritis, a disease characterized by severe <a href=\"http:\/\/en.wikipedia.org\/wiki\/Inflammation\">inflammation<\/a>, renal function impairment and eventual scarring, and which remains a major cause of end-stage-renal disease worldwide. &#8230; The researchers divided 27 rats into three groups, two of which were modeled with an induced pyelonephritis in their right kidneys, while the third group did not have induced disease. RPCs were obtained from the diseased animals&#8217; left kidneys and injected into the right kidney six weeks later. Two weeks after injection, tubular atrophy was reduced. After four weeks, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Fibrosis\">fibrosis<\/a> was reduced and after sixty days, right renal tissue integrity was &#8217;significantly improved.&#8217; &#8230; We propose that kidney augmentation was mainly due to functional tissue regeneration following cellular transplantation. Kidney-specific stem\/progenitor cells might be the most appropriate candidates for transplantation because of their inherent organ-specific <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_differentiation\">differentiation<\/a> and their capacity to modulate tissue remodeling in <a href=\"http:\/\/en.wikipedia.org\/wiki\/Nephropathy\">chronic nephropathies<\/a>. &#8230; The researchers concluded that because renal fibrosis is a common and ultimate pathway leading to end-stage renal disease, amelioration of fibrosis might be of major clinical relevance.&#8221;<\/p>\n<p><span>Link: <a href=\"http:\/\/www.eurekalert.org\/pub_releases\/2011-02\/ctco-sct021411.php\">http:\/\/www.eurekalert.org\/pub_releases\/2011-02\/ctco-sct021411.php<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A promising open access study: &#8220;Transplanting autologous renal progenitor cells (RPCs), (kidney stem cells derived from self-donors), into rat models with kidney damage from pyelonephritis &#8211; a type of urinary infection that has reached the kidney &#8211; has been found &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/stem-cells-versus-kidney-damage.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1041784","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041784"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1041784"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041784\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1041784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1041784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1041784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}