{"id":1041638,"date":"2010-08-01T08:16:37","date_gmt":"2010-08-01T08:16:37","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/lessons-from-the-mouse\/"},"modified":"2024-08-17T16:50:43","modified_gmt":"2024-08-17T20:50:43","slug":"lessons-from-the-mouse","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/lessons-from-the-mouse.php","title":{"rendered":"Lessons From the Mouse"},"content":{"rendered":"<p>A reminder of the role of the laboratory mouse in aging research: &#8220;Aging, which affects all organ systems, is one of the most complex <a href=\"http:\/\/en.wikipedia.org\/wiki\/Phenotype\">phenotypes<\/a>. Recent discoveries in long-lived mutant mice have revealed molecular mechanisms of longevity in mammals which may contribute to our understanding of why humans age. These mutations include naturally-occurring spontaneous mutations, and those of mice genetically modified by <a href=\"http:\/\/en.wikipedia.org\/wiki\/Genetic_engineering\">modern genomic technologies<\/a>. It is generally believed that the most fundamental mechanisms of aging are <a href=\"http:\/\/en.wikipedia.org\/wiki\/Conserved_sequence\">evolutionarily conserved<\/a> across species. The following types of longevity mechanisms have been intensively studied: suppression of the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Somatotrope\">somatotropic<\/a> (<a href=\"http:\/\/en.wikipedia.org\/wiki\/Growth_hormone\">growth hormone<\/a>\/<a href=\"http:\/\/www.fightaging.org\/archives\/2008\/10\/some-papers-on-igf1-and-insulin-in-aging.php\">insulin-like growth factor 1<\/a>) axis, decreased metabolism and increased resistance of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxidative_stress\">oxidative stress<\/a>, reduced <a href=\"http:\/\/en.wikipedia.org\/wiki\/Insulin\">insulin<\/a> secretion and increased <a href=\"http:\/\/en.wikipedia.org\/wiki\/Insulin_sensitivity\">insulin sensitivity<\/a>, and delayed reproductive maturation and reduced fertility. In addition, many of the mutations have a <a href=\"http:\/\/www.fightaging.org\/archives\/2009\/06\/a-maleonly-longevity-mutation-in-mice.php\">sex-dependent effect on lifespan<\/a>, and when present in different genetic backgrounds, the effects of the same gene mutation can vary considerably. &#8230; We anticipate that these mouse studies will ultimately provide clues about how to delay the aging and prolong lifespan, and help to develop therapies for healthier human aging.&#8221;<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20667513\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20667513<\/a><\/p>\n<p>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A reminder of the role of the laboratory mouse in aging research: &#8220;Aging, which affects all organ systems, is one of the most complex phenotypes. Recent discoveries in long-lived mutant mice have revealed molecular mechanisms of longevity in mammals which &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/lessons-from-the-mouse.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-1041638","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041638"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1041638"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1041638\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1041638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1041638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1041638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}