(UroToday.com) In this study, the authors present a retrospective analysis of the co-occurrence between actionable gene mutations and microsatellite instability-high status from next-generation sequencing of 20,296 tumors collected by 3D Medicines, a precision medicine company in China. <\/p>\n
The cohort is shown below. Fusions that were considered actionable include those involving ALK, RET, ROS1, FGFR1-4 and NTRK1-3 genes.<\/p>\n<\/p>\n
The incidence of MSI-H status was highest in the uterine cancer subcohort (11%). No information was provided regarding how MSI status was ascertained. <\/p>\n<\/p>\n
The incidence of actionable fusions is shown below, with lung cancers harboring the highest incidence of these genomic events (6.4%). ALK mutations were the most common fusion detected across all samples. <\/p>\n<\/p>\n
The greatest differences in fusion status with microsatellite status was observed in intestinal cancers. Only 0.2% (9\/4507) of microsatellite stable intestinal cancers had actionable fusions, but 4.2% of MSI-H (16\/384)patients harbored actionable fusions, predominantly in NTRK. <\/p>\n<\/p>\n
Cases with both MSI-H and actionable fusions were profiled for mRNA expression of immune-related genes, with a suggestion of higher expression levels of TMEM173 as well as multiple MHC II genes.<\/p>\n<\/p>\n
These results provide additional information regarding the incidence of high levels of microsatellite instability and certain genomic fusions across a variety of cancer subtypes, and identify specific rates of co-occurrence between fusions and MSI-H. These cases show up-regulation of certain immune-related genes even relative to MSI-H tumors lacking the fusions, with potential consequences for response to immunotherapy. <\/p>\n
Presented by: Tao Fu, Peking University Cancer Hospital, Beijing, China<\/p>\n
Written by: Alok Tewari, MD, PhD, Medical Oncologist at the Dana-Farber Cancer Institute, at the 2020 European Society for Medical Oncology Virtual Congress (#ESMO20), September 19th-September 21st, 2020. <\/p>\n
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Read the original here: (UroToday.com) In this study, the authors present a retrospective analysis of the co-occurrence between actionable gene mutations and microsatellite instability-high status from next-generation sequencing of 20,296 tumors collected by 3D Medicines, a precision medicine company in China. The cohort is shown below. Continue reading
\nESMO VIrtual Congress 2020: Co-Occurrence of Actionable Gene Fusions and Microsatellite Instability-High in... - UroToday<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"